参芪麦味地黄汤加减治疗2型糖尿病疗效及其对血脂代谢的影响

Curative Effect of Shenqi Maiwei Dihuang Decoction on Type 2 Diabetes Mellitus and Its Influence on Lipid Metabolism

目的 分析应用参芪麦味地黄汤加减治疗2型糖尿病患者的疗效、对血脂代谢的影响。方法 选取2022年7月—2023年7月溧阳市中医医院收治的50例2型糖尿病患者为研究对象,采用随机数表法分为两组,各25例。对照组接受常规治疗,观察组接受常规加参芪麦味地黄汤加减治疗,对比两组中医证候积分、临床疗效、血糖和血脂代谢水平。结果 观察组中医证候积分低于对照组,差异有统计学意义(P<0.05);与对照组相比,观察组的治疗总有效率(96.00%)较高,差异有统计学意义(χ^(2)=5.357,P<0.05);与对照组相比,观察组空腹血糖、餐后2 h血糖以及糖化血红蛋白水平较低,空腹C肽以及餐后2 hC肽较高,差异有统计学意义(P均<0.05);观察组高密度脂蛋白胆固醇较高,总胆固醇、三酰甘油以及低密度脂蛋白胆固醇较低,差异有统计学意义(P均<0.05)。结论 针对2型糖尿病患者,采用参芪麦味地黄汤加减治疗方法,有助于改善临床症状,降低血糖以及调节血脂代谢水平,提高临床疗效。

Objective To analyze the effect of Shenqi Maiwei Dihuang Decoction on type 2 diabetes and its influence on blood lipid metabolism.Methods A total of 50 patients with type 2 diabetes who were admitted to Liyang Hospital of Traditional Chinese Medicine from July 2022 to July 2023 were selected as the research objects.According to the random number table method,they were divided into two groups,with 25 cases in each group.The control group re-ceived conventional treatment,and the observation group received conventional treatment combined with Shenqi Mai-wei Dihuang decoction.The TCM syndrome score,clinical efficacy,blood glucose and lipid metabolism levels were compared between the two groups.Results The TCM syndrome score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);compared with the control group,the total effective rate(96.00%)of the observation group was higher,and the difference was statistically significant(χ^(2)=5.357,P<0.05);compared with control group,the levels of fasting blood glucose,2-hour postprandial blood glucose and gly-cosylated hemoglobin A1c in the observation group were lower,and the levels of fasting C-peptide and 2-hour post-prandial C-peptide were higher,and the differences were statistically significant(all P<0.05).The high density lipo-protein cholesterol in the observation group was higher,and the total cholesterol,triglyceride and low density lipopro-tein cholesterol were lower,the differences were statistically significant(all P<0.05).Conclusion For patients with type 2 diabetes mellitus,the Shenqi Maiwei Dihuang Decoction is helpful to improve clinical symptoms,reduce blood glucose and regulate lipid metabolism,and improve clinical efficacy.