硫辛酸注射液联合胰激肽原酶肠溶片对DPN的临床疗效及生存质量的影响

Effect of Lipoic Acid Injection Combined with Pancreatic Kininogenase Enteric-coated Tablets on Clinical Efficacy and Quality of Survival in DPN

目的 探讨硫辛酸注射液联合胰激肽原酶肠溶片对2型糖尿病周围神经病变(Diabetic Peripheral Neuropathy, DPN)患者的临床疗效、生存质量及安全性的影响。方法 选取2021年2月—2022年4月濉溪县中医医院60名DPN患者作为研究对象。通过随机数表法分为两组,每组30例。对照组采用常规治疗,观察组在对照组基础上加用硫辛酸注射液和胰激肽原酶肠溶片治疗。比较两组患者的神经病变评分、神经电生理指标、生存质量评分、安全性指标和不良反应发生率。结果 治疗后,观察组神经病变评分(6.2±0.9)分低于对照组(7.6±1.1)分,差异有统计学意义(t=5.438,P<0.05);观察组神经电生理指标、生存质量评分、安全性指标均优于对照组,差异有统计学意义(P均<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 硫辛酸注射液联合胰激肽原酶肠溶片对DPN患者有良好的临床疗效,能够改善神经功能、改善神经电生理指标、提高生存质量,且安全性高。

Objective To investigate the effects of lipoic acid injection combined with pancreatic kininogenase enteric-coated tablets on the clinical efficacy,quality of survival and safety of patients with type 2 diabetic peripheral neuropathy(DPN).Methods 60 DPN patients admitted to Suixi County Hospital of Traditional Chinese Medicine from February 2021 to April 2022 were selected as the study objects.They were divided into two groups with 30 cases in each group by random number table method.The control group received conventional treatment,and the observation group was treated with lipoic acid injection and pancreatic kininogenase enteric-coated tablets on the basis of control group.Neuropathy score,neuroelectrophysiological index,quality of life score,safety index and incidence of adverse reactions were compared between the two groups.Results After treatment,the neuropathy score of observation group(6.2±0.9)points was lower than that of control group(7.6±1.1)points,and the difference was statistically significant(t=5.438,P<0.05).Neuroelectrophysiological indexes,quality of survival scores and safety indexes of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Li-poic acid injection combined with pancreatic kininogenase enteric-coated tablets has good clinical efficacy in DPN pa-tients,which can improve nerve function,improve nerve electrophysiological indexes,improve life quality,and have high safety.