硫辛酸治疗急性脑梗死合并2型糖尿病的临床疗效分析

Clinical Effect of Lipoic Acid on Acute Cerebral Infarction Complicated with Type 2 Diabetes Mellitus

目的 分析硫辛酸治疗急性脑梗死合并2型糖尿病的临床疗效。方法 选取2022年7月—2023年7月石狮市医院神经内科收治的60例急性脑梗死合并2型糖尿病患者为研究对象,经随机数表法分为对照组和观察组,每组30例。两组均进行阿替普酶溶栓治疗,对照组联用胰岛素治疗,观察组联用胰岛素、硫辛酸治疗,比较两组血糖水平、胰岛功能、治疗效果。结果 治疗2周后,观察组血糖水平、空腹胰岛素、胰岛素抵抗指数水平较对照组更低,胰岛β细胞功能水平较对照组更高,差异有统计学意义(P均<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论 急性脑梗死合并2型糖尿病采用硫辛酸治疗,可控制血糖、改善胰岛功能,提升治疗效果。

Objective To analyze the clinical effect of lipoic acid on acute cerebral infarction complicated with type 2 diabetes.Methods 60 patients with acute cerebral infarction complicated with type 2 diabetes admitted to the Depart-ment of Neurology of Shishi Hospital from July 2022 to July 2023 were selected as the study objects,and were divided into control group and observation group by random number table method,with 30 cases in each group.The two groups were treated with alteplase thrombolytic therapy,the control group was treated with insulin,and the observation group was treated with insulin and lipoic acid.The blood glucose level,islet function and therapeutic effect of the two groups were compared.Results After 2 weeks of treatment,the blood glucose level,fasting insulin and insulin resis-tance index of observation group were lower than those of control group,and the function level of isletβcells was higher than that of control group,and the differences were statistically significant(all P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Lipoic acid therapy for acute cerebral infarction complicated with type 2 diabetes can control blood glucose levels improve islet function and enhance therapeutic effect.