达格列净对不稳定心绞痛合并2型糖尿病冠脉介入治疗后的疗效及对糖脂代谢指标的影响

Effect of Dapagliflozin on Patients with Unstable Angina Pectoris Complicated with Type 2 Diabetes Mellitus after Coronary Intervention and on Glucose and Lipid Metabolism Indexes

目的 探讨达格列净对不稳定心绞痛合并2型糖尿病冠脉介入治疗后的疗效及对糖脂代谢指标的影响。方法 选取2021年1—5月东营市中医院心病一科收治的70例不稳定心绞痛合并2型糖尿病的患者为研究对象,按随机数表法分为对照组和观察组,每组35例。两组患者在治疗的过程中均采用抗血小板以及抗凝等基础性治疗方法,对照组使用二甲双胍进行降糖治疗,观察组在对照组治疗基础上使用达格列净片进行治疗。比较两组患者糖脂代谢指标、控制血糖疗效率。结果 治疗后,观察组糖化血红蛋白、空腹血糖、餐后2 h血糖、总胆固醇和三酰甘油水平均低于对照组,差异有统计学意义(P均<0.05)。对照组控糖总有效率低于观察组,差异有统计学意义(P<0.05)。结论 达格列净在不稳定心绞痛合并2型糖尿病患者中可能具有多重治疗效益,显著改善患者糖脂代谢水平,降低患者血糖,提升患者控糖疗效。

Objective To investigate the effect of dapagliflozin on unstable angina pectoris complicated with type 2 diabetes after coronary intervention and its effects on glucose and lipid metabolism.Methods 70 patients with un-stable angina combined with type 2 diabetes mellitus admitted to the Department of CardiologyⅠof Dongying Hospi-tal of Traditional Chinese Medicine from January to May 2021 were selected as the study objects and divided into the control group and the observation group according to the method of random number table,with 35 cases in each group.Both groups of patients were treated with basic treatment such as antiplatelet and anticoagulation.The control group was treated with metformin,and the observation group was treated with dapagliflozin tablets on the basis of the treat-ment of the control group.Compared the glycemic and lipid metabolism indexes and glycemic control efficacy rate of the two groups.Results After treatment,the levels of glycosylated hemoglobin,fasting plasma glucose,2-hour post-prandial plasma glucose,total cholesterol and triacylglycerol in the observation group were all lower than those in the control group,and the differences were statistically significant(all P<0.05).The total effective rate of glycemic control in the control group was lower than that in the observation group,and the difference was statistically significant(P<0.05).Conclusion Dagliflozin may have multiple therapeutic benefits in patients with unstable angina combined with type 2 diabetes mellitus,significantly improving patients'glucose and lipid metabolism levels,lowering patients'blood glucose,and enhancing patients'glycemic control efficacy.