改良葛根芩连汤辅助治疗对老年糖尿病周围神经病变患者血糖水平、神经传导速度的影响

Effect of Modified Gegen Qinlian Decoction on Blood Glucose Level and Nerve Conduction Velocity in Elderly Patients with Diabetic Peripheral Neuropathy

目的 探讨改良葛根芩连汤辅助治疗对老年糖尿病周围神经病变(Diabetic Peripheral Neuropathy,DPN)患者血糖水平、神经传导速度的影响。方法 选取2020年1月—2023年1月福建省霞浦县医院收治的150例老年DPN患者为研究对象,按照随机数表法分组,每组75例,对照组用常规疗法,观察组在此基础上应用改良葛根芩连汤辅助治疗,比较两组血糖水平、神经传导速度。结果 观察组治疗1个月后餐后2 h血糖、空腹血糖、糖化血红蛋白均低于对照组,差异有统计学意义(P均<0.05);观察组治疗1个月后正中神经、腓总神经的感觉神经传导速度、运动神经传导速度均高于对照组,差异有统计学意义(P均<0.05);观察组治疗1个月后脘腹痞满、肢体灼痛、麻木不仁、重着乏力评分均低于对照组,多伦多临床评分系统评分低于对照组,差异有统计学意义(P均<0.05)。结论 改良葛根芩连汤辅助治疗对老年DPN患者血糖水平具有降低作用,且能改善神经传导速度,减轻症状。

Objective To investigate the effects of modified Gegen Qinlian Decoction on blood glucose level and nerve conduction velocity in elderly patients with diabetic peripheral neuropathy(DPN).Methods A total of one hundred and fifty elderly patients with DPN admitted to Xiapu County Hospital of Fujian Province from January 2020 to Janu-ary 2023 were selected as the research objects and divided into groups according to the random number table method,75 patients in each group.The control group was treated with conventional therapy,and the observation group was treated with modified Gegen Qinlian Decoction on this basis.Blood glucose level and nerve conduction velocity were compared between the two groups.Results 2 h postprandial blood glucose,fasting blood glucose and glycated hemo-globin in the observation group were lower than those in the control group after 1 month of treatment,and the differ-ence was statistically significant(all P<0.05);after 1 month of treatment,sensory nerve conduction velocity and motor nerve conduction velocity of median nerve and common peroneal nerve in observation group were higher than those of control group,and the difference was statistically significant(both P<0.05);after 1 month of treatment,the scores of epigastric fullness,limb burning pain,numbness and heavy fatigue of the observation group were lower than those of the control group,and the scores of the Toronto clinical scoring system were lower than those of the control group,the differences were statistically significant(all P<0.05).Conclusion Modified Gegen Qinlian Decoction can reduce blood glucose level in elderly DPN patients,improve nerve conduction speed and alleviate symptoms.