细胞衰老与特发性肺纤维化相关机制的研究进展

Research progress on the mechanism of cell senescenceassociated with idiopathic pulmonary fibrosis

特发性肺纤维化(IPF)是一种随着年龄增长逐渐加重,主要表现为活动性呼吸困难,进行性加重,且不可逆的疾病。细胞衰老是衰老的标志,其定义是响应细胞损伤和压力而稳定退出细胞周期。在IPF中,导致细胞衰老的机制包括端粒功能障碍、DNA损伤、细胞衰老表型、线粒体功能障碍、炎症反应及自噬失调等,随着对衰老相关的研究进步,IPF与细胞衰老的研究也愈演愈烈,该文就这些因素与IPF的发生发展关系进行综述。

Idiopathic pulmonary fibrosis(IPF)is an irreversible disease that gradually increases with age,mainly manifested as active dyspnea and progressive progressive worsening,and irreversible.Cell senescence is a sign of aging,which is defined as a stable exit from the cell cycle in response to cell damage and stress.In IPF,the mechanisms that lead to cell senescence include telomere dysfunction,DNA damage,cell senescence phenotype,mitochondrial dysfunction,inflammatory response and autophagy disorder.With the progress of aging-related research,the relationship between IPF and cell senescence has become more and more intense.This article reviewed the relationship between these factors and the occurrence and development of IPF.