药学干预对抗生素临床合理应用的影响

Impact of Pharmaceutical Intervention on Rational Clinical Application of Antibiotics

目的:分析药学干预对抗生素临床合理应用的影响。方法:选取2023年1—12月于上海瑞东医院行抗生素治疗的患者62例作为研究对象,依据随机数字表法分为对照组与观察组,各31例。对照组实施常规用药指导,观察组在对照组基础上实施药学干预。比较两组抗生素认知度、用药依从性、不良反应发生情况、不合理用药情况、满意度。结果:干预前,两组抗生素认知度、用药依从性评分比较,差异无统计学意义(P>0.05);干预后,两组抗生素认知度、用药依从性评分高于干预前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.047)。观察组不合理用药发生率低于对照组,差异有统计学意义(P=0.038)。观察组总满意度高于对照组,差异有统计学意义(P=0.045)。结论:药学干预能够提高患者对抗生素的认知度、用药依从性以及满意度,减少不良反应及不合理用药情况,值得临床应用。

Objective:To analyze the impact of pharmaceutical interventions on the rational clinical application of antibiotics.Methods:A total of 62 patients treated with antibiotics at Shanghai Ruidong Hospital from January 2023 to December 2023 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 31 cases in each group.The control group received routine medication guidance,while the observation group received pharmaceutical intervention on the basis of the control group.The antibiotics awareness,medication compliance,adverse reactions,irrational drug use and satisfaction were compared between two groups.Results:Before intervention,there was no significant difference in antibiotics awareness and medication compliance scores between the two groups(P>0.05);After intervention,the antibiotics awareness and medication compliance scores in the two groups were higher than those before intervention,and the scores in the observation group were higher than those in the control group,with a statistically significant difference(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.047).The incidence of irrational drug use in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.038).The total satisfaction in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.045).Conclusion:Pharmaceutical intervention improves the antibiotics awareness,medication compliance and satisfaction of patients,reduces adverse reactions and irrational drug use,and deserves clinical application.