利培酮联合无抽搐电休克治疗女性慢性精神分裂症的效果分析

Effect Analysis of Risperidone Combined with Non-Convulsive Electroconvulsive Therapy in Treatment of Chronic Schizophrenia in Women

目的:分析利培酮联合无抽搐电休克治疗女性慢性精神分裂症的效果。方法:选取2022年1月—2023年5月徐州市东方人民医院收治的70例慢性精神分裂症女性患者作为研究对象,以随机数字表法分为两组,各35例。对照组采用利培酮治疗,观察组在对照组基础上采用无抽搐电休克治疗。比较两组治疗效果。结果:两组不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗前,两组5-羟色胺(5-HT)、多巴胺(DA)以及去甲肾上腺素(NE)水平比较,差异无统计学意义(P>0.05);治疗后,两组5-HT、DA、NE水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组阳性症状、阴性症状、一般精神病理评分及总分比较,差异无统计学意义(P>0.05);治疗后,两组阳性症状、阴性症状、一般精神病理评分及总分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.022)。结论:利培酮联合无抽搐电休克治疗女性慢性精神分裂症的效果较好,可以改善患者神经递质水平与临床症状,且不会增加不良反应。

Objective:To analyze the effect of risperidone combined with non-convulsive electroconvulsive therapy in the treatment of chronic schizophrenia in women.Methods:A total of 70 female patients with chronic schizophrenia admitted to Xuzhou Oriental People's Hospital from January 2022 to May 2023 were selected as the study subjects.They were divided into two groups using a random number table method,with 35 cases in each group.The control group received treatment with risperidone,while the observation group received non-convulsive electroconvulsive therapy on the basis of the control group.The therapeutic effects of the two groups were compared.Results:There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Before treatment,there was no significant difference in the levels of serotonin(5-HT),dopamine(DA)and norepinephrine(NE)between the two groups(P>0.05);After treatment,the levels of 5-HT,DA and NE in the two groups were higher than those before treatment,and the levels of 5-HT,DA and NE in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference between the two groups in terms of positive symptoms,negative symptoms,general psychopathological scores and total scores(P>0.05);After treatment,the positive symptoms,negative symptoms,general psychopathological scores and total scores in the two groups were lower than those before treatment,and the scores in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.022).Conclusion:The combination of risperidone and non-convulsive electroconvulsive therapy has good effects in the treatment of chronic schizophrenia in women,and can improve the levels of neurotransmitters and clinical symptoms of patients,and will not increase adverse reactions.