丁苯酞联合多奈哌齐治疗老年脑卒中后认知障碍的效果

Effect of butylphthalide combined with donepezil in the treatment of post-stroke cognitive impairment in the elderly

目的 探究老年脑卒中后认知障碍患者应用丁苯酞联合多奈哌齐治疗的效果。方法 92例老年脑卒中后认知障碍患者,采用计算机随机分为观察组和对照组,每组46例。观察组应用丁苯酞联合多奈哌齐治疗,对照组应用丁苯酞治疗。比较两组患者的临床疗效、蒙特利尔认知评估量表(MoCA)评分以及日常生活能力。结果 观察组的治疗总有效率95.65%高于对照组的82.61%(P<0.05)。治疗1个月后,观察组的视空间与执行力、语言功能、注意力、记忆力、抽象概括能力、定向力、命名评分及总分分别为(3.97±0.34)、(2.35±0.46)、(4.75±0.22)、(4.69±0.48)、(1.89±0.42)、(5.76±0.35)、(2.87±0.32)、(25.38±3.44)分,均高于对照组的(3.49±0.23)、(1.74±0.34)、(4.10±0.45)、(3.46±0.68)、(1.16±0.48)、(5.18±0.12)、(2.35±0.43)、(22.34±3.28)分(P<0.05)。治疗1周以及1个月后,观察组的Barthel指数分别为(67.05±4.38)、(75.65±5.13)分,明显高于对照组的(55.46±4.78)、(69.84±5.06)分(P<0.05)。结论 老年脑卒中后认知障碍患者选择应用丁苯酞联合多奈哌齐治疗具有明显疗效,还可促进患者的日常生活能力的提升,值得应用。

Objective To explore the effect of butylphthalide combined with donepezil in the treatment of post-stroke cognitive impairment in the elderly.Methods 92 elderly patients with post-stroke cognitive impairment were randomly divided into an observation group and a control group by computer,with 46 cases in each group.The observation group was treated with butylphthalide and donepezil,and the control group was treated with butylphthalide.The clinical efficacy,Montreal cognitive assessment scale(MoCA)score and activities of daily living were compared between the two groups.Results The total effective rate of the observation group was 95.65%,which was higher than 82.61%of the control group(P<0.05).After 1 month of treatment,the scores of visual space and executive power,language function,attention,memory,abstract generalization ability,orientation,naming and total score of the observation group were(3.97±0.34),(2.35±0.46),(4.75±0.22),(4.69±0.48),(1.89±0.42),(5.76±0.35),(2.87±0.32)and(25.38±3.44)points,which were higher than(3.49±0.23),(1.74±0.34),(4.10±0.45),(3.46±0.68),(1.16±0.48),(5.18±0.12),(2.35±0.43)and(22.34±3.28)points in the control group(P<0.05).After 1 week and 1 month of treatment,the Barthel index in the observation group were(67.05±4.38)and(75.65±5.13)points,which were significantly higher than(55.46±4.78)and(69.84±5.06)points in the control group(P<0.05).Conclusion The combination of butylphthalide and donepezil in the treatment of elderly patients with post-stroke cognitive impairment has obvious curative effect,and can also promote the improvement of patients'activities of daily living,which is worthy of application.