硫辛酸胶囊联合甲钴胺片治疗糖尿病周围神经病变的临床疗效

Clinical Efficacy of Lipoic Acid Capsules Combined with Mecobalamin Tablets in the Treatment of Diabetic Peripheral Neuropathy

目的 分析硫辛酸胶囊的基础上辅助甲钴胺片治疗糖尿病周围神经病变(DPN)患者的临床效果。方法 本文的研究对象为80例糖尿病周围神经病变患者,根据随机数字法主要分为观察组与对照组。对照组40例患者均以甲钴胺片进行治疗,观察组40例患者均以硫辛酸胶囊联合甲钴胺片治疗。对比两组的临床疗效、运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)、多伦多临床评分系统(TCSS)评分。结果 对比于对照组,观察组患者的总有效率明显较高(P<0.05)。治疗后,与对照组对比,观察组患者MNCV与SNCV升高(P<0.05)。治疗后与对照组对比,观察组患者的TCSS评分较低(P<0.05)。结论 以硫辛酸胶囊辅助甲钴胺片治疗DPN患者可改善运动神经传导速度、感觉神经传导速度,延缓疾病进展,提升治疗效果,值得临床借鉴、推广。

Objective To analyze the clinical efficacy of treating diabetic peripheral neuropathy(DPN)patients with a combination of lipoic acid capsules and mecobalamin tablets beyond the use of mecobalamin alone.Methods This study involved 80 patients with diabetic peripheral neuropathy.Using a random number method,they were divided into an observation group and a control group,with 40 patients in each.The control group was treated exclusively with mecobalamin tablets,while the observation group received a combination treatment of lipoic acid capsules and mecobalamin tablets.The clinical efficacy,motor nerve conduction velocity(MNCV),sensory nerve conduction velocity(SNCV),and the scores from the Toronto Clinical Scoring System(TCSS)were compared between the two groups.Results Compared to the control group,the observation group showed a significantly higher overall effective rate(P<0.05).After treatment,there was an improvement in MNCV and SNCV in the observation group as compared to the control group(P<0.05).Furthermore,following the treatment,the TCSS scores of patients in the observation group were lower than those in the control group(P<0.05).Conclusion The adjuvant treatment with lipoic acid capsules to mecobalamin tablets can improve motor and sensory nerve conduction velocity,slow the progression of the disease,and enhance the therapeutic effect.This approach is worthy of clinical reference and promotion.