生理性海水联合布地奈德鼻喷雾剂治疗变应性鼻炎的临床疗效观察

Observation on the clinical efficacy of physiological seawater combined with budesonide nasal spray in the treatment of allergic rhinitis

目的 分析生理性海水联合布地奈德鼻喷雾剂治疗变应性鼻炎(AR)的临床疗效。方法 选取120例变应性鼻炎患者,按治疗方案不同分为试验组和对照组,每组60例。试验组患者采用生理性海水联合布地奈德鼻喷雾剂治疗,对照组单独使用布地奈德鼻喷雾剂治疗。比较两组患者自觉症状改善时间、不良反应发生情况及治疗前后症状评分。结果 试验组患者治疗前症状评分为(2.32±0.36)分,对照组患者治疗前症状评分为(2.34±0.48)分;试验组患者治疗后症状评分为(1.03±0.33)分,对照组患者治疗后症状评分为(1.43±0.57)分;治疗前,两组症状评分比较无统计学差异(P>0.05);治疗后,两组症状评分均较治疗前下降明显,且试验组评分低于对照组,差异有统计学意义(P<0.05)。试验组患者自觉症状改善时间为(9.13±1.31)d,对照组患者自觉症状改善时间为(15.34±3.41)d;试验组自觉症状改善时间明显短于对照组,差异有统计学意义(P<0.05)。试验组未发生不良反应,对照组发生2例(3.33%)鼻腔干燥症状;两组不良反应发生率无差异性(P>0.05)。结论 变应性鼻炎患者使用生理性海水联合布地奈德鼻喷雾剂治疗相较于单独使用布地奈德鼻喷雾剂治疗,可以明显改善患者的临床症状、体征,缩短症状改善,提高治疗安全性。

Objective To analyze the clinical efficacy of physiological seawater combined with budesonide nasal spray in the treatment of allergic rhinitis(AR).Methods A total of 120 patients with allergic rhinitis were divided into an experimental group and a control group according to different treatment regimen,with 60 cases in each group.The experimental group was treated with physiological seawater and budesonide nasal spray,and the control group was treated with budesonide nasal spray.The symptom improvement time,occurrence of adverse reactions and symptom scores before and after treatment were compared between the two groups.Results Before treatment,the symptom score of the experimental group was(2.32±0.36)points,and that of the control group was(2.34±0.48)points.After treatment,the symptom score of the experimental group was(1.03±0.33)points,and that of the control group was(1.43±0.57)points.Before treatment,there was no significant difference in symptom scores between the two groups(P>0.05).After treatment,the symptom score in both groups decreased significantly compared with that before treatment,and the experimental group was lower than the control group.The difference was statistically significant(P<0.05).The symptom improvement time of the experimental group was(9.13±1.31)d,and that of the control group was(15.34±3.41)d.The symptom improvement time in the experimental group was significantly shorter than that in the control group,and the difference was statistically significant(P<0.05).There were no adverse reactions in the experimental group and 2 cases(3.33%)in the control group.There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For patients with allergic rhinitis,compared with the use of budesonide nasal spray alone,physiological seawater combined with budesonide nasal spray can significantly improve the symptoms and signs of patients,shorten the treatment process and improve the safety of treatment.