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基于列线图的结直肠癌影响因素分析

Analysis of influencing factors of colorectal cancer based on nomogram
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摘要 目的 通过了解结直肠癌发病相关影响因素,构建列线图,更好地识别结直肠癌危险人群。方法 选取2020年10月至2023年3月四川省7家医疗机构半年内确诊为结直肠癌的368例患者作为病例组,选取同期体检的380例一般人群作为对照组,对其进行问卷调查,采用多因素logistic回归分析结直肠癌相关影响因素,构建结直肠癌影响因素列线图,对模型进行内部验证,评估稳定性。结果 多因素logistic回归分析结果显示,农民(OR=3.527,95%CI:1.451~8.576)、偏好动物油(OR=3.789,95%CI:1.270~11.251)、含糖饮料(OR=1.921,95%CI:1.200~3.075)、不吃钙片(OR=2.011,95%CI:1.311~3.085)会增加结直肠癌发生危险;个人年收入越高(OR=0.482,95%CI:0.288~0.808;OR=0.126,95%CI:0.053~0.299)、没有肠道息肉(OR=0.169,95%CI:0.104~0.274)、不吃重油脂食物(OR=0.432,95%CI:0.272~0.688)、轻度体力劳动(OR=0.220,95%CI:0.122~0.397)会降低结直肠癌发生危险。列线图准确率为74.3%,受试者工作特征(ROC)曲线下面积为0.836,模型具有良好区分度和可靠性。结论 列线图可视化肠癌影响因素,利于其防治工作开展。 Objective To better identify the risk population of colorectal cancer by understanding the related influencing factors of colorectal cancer and constructing nomogram.Methods From October 2020 to March 2023,a total of 368 patients diagnosed with colorectal cancer in seven medical institutions in Sichuan Province were selected as the case group,and 380 general people in the same period were selected as the control group.The questionnaire survey was conducted,and the related influencing factors of colorectal cancer were analyzed by multivariate logistic regression,and the nomogram of influencing factors of colorectal cancer was constructed.The model was verified internally,and its stability was evaluated.Results The results of multivariate logistic regression analysis showed that farmers(OR=3.527,95%CI:1.451-8.576),preference for animal oil(OR=3.789,95%CI:1.270-11.251),sugary drinks(OR=1.921,95%CI:1.200-3.075),and not taking calcium tablets(OR=2.011,95%CI:1.311-3.085)increased the risk of colorectal cancer;higher annual personal income(OR=0.482,95%CI:0.288-0.808;OR=0.126,95%CI:0.053-0.299),absence of intestinal polyps(OR=0.169,95%CI:0.104-0.274),no heavy fatty foods(OR=0.432,95%CI:0.272-0.688),and light physical work(OR=0.220,95%CI:0.122-0.397)would reduce the risk of colorectal cancer.The accuracy of nomogram was 74.3%,and the area under the receiver operating characteristic(ROC)curve was 0.836,the model had good discrimination and reliability.Conclusion The Nomogram can visualize influencing factors of colorectal cancer,which is beneficial to its prevention and treatment.
作者 李玉婷 王青青 易芳 杨中华 张铃林 容丽楼 李菊 万绍平 LI Yuting;WANG Qingqing;YI Fang;YANG Zhonghua;ZHANG Linglin;RONG Lilou;LI Ju;WAN Shaoping(School of Public Health,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 611137,China;Department of Science and Technology,Sichuan Clinical Research Center for Cancer/Sichuan Cancer Hospital&Institute/Sichuan Cancer Center/Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu,Sichuan 610041,China)
出处 《重庆医学》 CAS 2024年第6期811-818,共8页 Chongqing medicine
基金 四川省科学技术厅对口科技援助项目(2021YFQ0032)。
关键词 结直肠癌 病例对照研究 影响因素分析 LOGISTIC回归 列线图 colorectal cancer case-control study analysis of influencing factors logistic regression nomogram
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