卵巢移植后缺血再灌注损伤改善方法研究进展

Advances in the treatment of ischemia-reperfusion injury after ovarian transplantation

卵巢移植可在一定时间内有效保留及延长女性恶性肿瘤患者的卵巢生育功能,在不受激素刺激情况下保存大量卵泡,适用于卵巢早衰的高风险女性。但卵巢移植过程中涉及的技术难题较多,其中移植后缺血再灌注对卵巢移植成功率及移植成功后卵巢功能的影响较大。本文就卵巢移植后缺血再灌注损伤机制、改善方法的研究进展作一综述。

Ovarian transplantation can effectively preserve and prolong the reproductive function of female cancer patients,and preserve a large number of follicles without hormone stimulation,which is suitable for women at high risk of premature ovarian failure.There are still many technical problems involved in the transplantation process,among which ischemia-reperfusion after transplantation has a great impact on the success rate of ovarian transplantation and ovarian function after successful transplantation.This paper reviews the research progress of the mechanism of ischemia-reperfusion injury after ovarian transplantation and methods of amelioration.