精子顶体酶活性在男性生殖中的价值研究进展

Advances in the study of sperm acrosome enzyme activity in male reproduction

据报道,全球有8%~12%的育龄夫妇受到不孕不育症的影响,其中男性因素约占50%的主要原因或促成因素。男性生育能力低下,包括先天性、后天性和特发性因素,这些因素可能会损害精子发生。近年来,精子顶体酶已成为男性不育领域的一研究热点。相关研究发现,精子中的顶体酶可能在精子受精和胚胎发育中起重要作用,精子顶体酶活性作为潜在的精子质量以及男性生殖生物标志,不仅为男性不育的评估开辟了新的视角,也为预测辅助生殖治疗结局提供了一定参考。本文主要从精子顶体酶的功能作用、影响因素及其辅助生殖治疗等方面,综述精子顶体酶活性与男性不育的相关性研究进展,以进一步阐明顶体酶活性在男性不育症诊断中的临床价值。

Infertility is reported to affect 8%-12%of couples of childbearing age worldwide,with male factors accounting for approximately 50%of the major causes or contributing factors.Low male fertility,including congenital,acquired and idiopathic factors,impairs spermatogenesis.In recent years,sperm acrosome enzymes have become a hot topic of research in the field of male infertility.Sperm acrosome enzymes may play an important role in sperm fertilisation and embryonic development.Sperm acrosome enzyme activity is a potential biomarker of sperm quality and male reproduction,which opens up new perspectives for the assessment of male infertility,and provides a reference for predicting the outcome of assisted reproduction treatment.In this paper,we reviewe the research progress of the correlation between sperm acrosome enzyme activity and male infertility from the perspectives of the functional role of sperm acrosome enzymes,their influencing factors and assisted reproductive treatment,thus further elucidating the clinical value of acrosome enzyme activity in the diagnosis of male infertility.