棕榈酸帕利哌酮注射液和奥氮平对精神分裂症患者的疗效、安全性以及社会功能的影响

Comparison of the efficacy,safety and social function of schizophrenia patienst after treatment by palmitic acid paliperidone injection or oral olanzapine

目的比较棕榈酸帕利哌酮(Paliperidone palmitate,PP1M)注射液和口服奥氮平片治疗精神分裂症的疗效、安全性及对患者社会功能的影响。方法在2021年8月~2022年12月期间,选择100例精神分裂症患者进行比较研究,使用随机数字表法将100例患者分为两组。其中,对照组50例患者,接受奥氮平治疗;研究组包括50例患者,接受PPIM注射液治疗,对比两组患者治疗前后阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评分减分率、社会功能量表(Social Functioning Scale,PSP)评分、社会功能缺陷筛选量表(Social disability screening Scale,SDSS)评分、催乳素(Prolactin,PRL)、空腹血糖(Fasting blood glucose,PBG)、不良反应总发生率。结果研究组PANSS减分率高于对照组,研究组治疗1周、2周、4周、6周、8周、12周后SDSS评分均低于对照组,差异均存在统计学意义(P<0.05)。研究组治疗1周、2周、4周、6周、8周、12周后PSP评分高于对照组,研究组的PRL水平显著高于对照组(P<0.05)。比较研究组和对照组的PBG时,我们并未观察到显著差异(P>0.05)。此外,研究组和对照组之间的不良反应总发生率也没有显著差异(研究组为8.00%,对照组为10.00%,P>0.05)。结论PPIM注射液可更有效的改善精神分裂症患者临床症状及社会功能,且不良反应发生率较低,但会引起催乳素增高,故精神分裂症患者在治疗期间应加强催乳素监测。

Objective To compare the efficacy,safety and social function of Palmitic acid Paliperidone(PP1M)injection and oral Olanzapine tablet in the treatment of schizophrenia.Methods From August 2021 to December 2022,100 patients with schizophrenia were selected and divided into two groups using a random number table method.Among them,the control group included 50 patients who received Olanzapine treatment;The study group included 50 patients who received PPIM injection,The reduction rate in scores of Positive and Negative Syndrome Scale(PANSS),Social Functioning Scale(PSP),Social Disability Screening Scale(SDSS),blood prolactin(PRL),fasting blood sugar(PBG)and total incidence of adverse reactions were compared between two groups.Results The PANSS reduction rate in the study group was higher than that in the control group,and the SDSS scores in the study group were lower than those in the control group after 1 week,2 weeks,4 weeks,6 weeks,8 weeks,and 12 weeks of treatment,with statistically significant differences(P<0.05).After 1 week,2 weeks,4 weeks,6 weeks,8 weeks,and 12 weeks of treat-ment,the PSP score of the study group was higher than that of the control group,and the PRL level of the study group was significantly higher than that of the control group(P<0.05).Comparing the PBG between the study group and the control group,we did not observe the significant difference(P>0.05).In addition,there was no significant difference in the total incidence of adverse reactions between the study group and the control group(8.00%in the study group and 10.00%in the control group)(P>0.05).Conclusion PPIM injection can more effectively improve the clinical symp-toms and social functions of schizophrenic patients,and the incidence of adverse reactions is low,but it will cause an increase in Prolactin.Therefore,Prolactin monitoring should be strengthened during the treatment of schizophrenic pa-tients.