髓源性抑制细胞在肿瘤血管生成中的研究进展

Research progress of myeloid-derived suppressor cells in tumor angiogenesis

髓源性抑制细胞(MDSC)作为一种免疫抑制细胞,是免疫微环境的重要组成部分,除了主要的促肿瘤免疫逃逸功能,近年研究发现,MDSC的促血管生成等非免疫学功能也能对肿瘤发展发挥促进作用。MDSC可通过血管内皮细胞生长因子信号通路直接促进肿瘤血管生成,也可通过分泌基质金属蛋白酶9、碱性成纤维细胞生长因子、血管生成肽Bv8、血小板衍生生长因子等细胞因子、外泌体或与其他细胞发生相互作用间接促进肿瘤生长和血管生成。探究MDSC的扩增活化、募集及促血管生成机制可为基于靶向MDSC的个体化诊疗提供新的思路。

As a kind of immunosuppressive cells,myeloid-derived suppressor cells(MDSCs)are an important component of the immune microenvironment.MDSCs play a significant role in promoting tumor immune escape.In addition,non-immunological functions such as promoting angiogenesis can also promote tumor development with the deepening of research.MDSCs can promote tumor angiogenesis directly through vascular endothelial growth factor signaling pathway,or promote tumor growth and angiogenesis by secreting cytokines such as matrix metalloprotein-9,basic fibroblast growth factor,angiogenic peptide Bv8,platelet derived growth factor,exosomes,or interacting with other cells.Exploring the expansion,activation,recruitment and angiogenesis mechanism of MDSCs will provide new ideas for regulating the individualized diagnosis and treatment based on targeted MDSCs.