精神压力对育龄期男性精液质量及性激素的影响

Effects of psychological stress on semen quality and sex hormones in men of childbearing age

目的 探究精神压力与男性精液质量及性激素的相关关系。方法 回顾性分析就诊于西安交通大学第一附属医院生殖科的120名男性患者的精液质量及性激素水平数据。采用压力感知量表(PSS-14)评估近期精神压力状况。根据WHO人类精液实验室检验手册(第五版)标准采用CASA方法分析精液质量数据,晨起空腹血清性激素检查采用电化学发光法进行检测。根据量表得分将患者分为低压力组(n=22)、中压力组(n=70)、高压力组(n=28),分析精神压力对育龄期男性精液质量及性激素的影响。结果 高压力组男性的精液量、精子浓度、前向运动百分数明显低于低压力组,其差异具有统计学意义(P<0.0001)。根据斯皮尔曼(Spearman)秩相关性分析,育龄期男性精液质量下降与精神压力负相关(P<0.05),其相关系数分别为–0.7603219、–0.7908883、–0.8205084;性激素参数的变化与精神压力相关性证据不足(P>0.05)。结论 精神压力的升高与育龄期男性精液质量下降有关。精神压力的高感知状态是影响精液质量的一个敏感指标,而与性激素水平缺乏关联。

Objective This study aimed to explore the relationship between psychological stress and semen quality,as well as sex hormone levels in males.Methods A retrospective analysis was performed on semen quality and sex hormone level data obtained from 120 male patients at the Reproductive Medicine Department of the First Affiliated Hospital of Xi'an Jiaotong University.The stress perception scale(PSS-14) was used to assess recent psychological stress semen quality were analyzed by computer-assisted sperm analysis(CASA) according to the World Health Organization's(WHO) manual of laboratory testing of human semen(5th edition).Fasting serum hormone levels were measured using electrochemiluminescence.The patients were divided into low stress group(n=22),moderate stress group(n=70),and high stress group(n=28) based on their PSS-14 scores and the effects of psychological stress on semen quality and sex hormones in men of childbearing age were analyzed.Results The semen volume,sperm concentration and percentage of forward motion in the high stress group were significantly lower than those in the low stress group,and the differences were statistically significant(P<0.0001).Spearman rank correlation analysis demonstrated a significant negative correlation between decreased semen quality in reproductive-age males and psychological stress(P<0.05),with correlation coefficients of -0.7603219,-0.7908883,and -0.8205084 for semen volume,sperm concentration,and forward motility,respectively.Nevertheless,there was insufficient evidence to establish a correlation between changes in sex hormone parameters and psychological stress(P>0.05).Conclusion Elevated psychological stress is associated with decreased semen quality in males of reproductive age.High perceived psychological stress acts as a sensitive indicator affecting semen quality,although lacking a significant association with sex hormone levels.