中药保留灌肠联合多西环素对慢性子宫内膜炎患者的临床研究

Clinical Study on Traditional Chinese Medicine Retention Enema Combined with Doxycycline in Patients with Chronic Endometritis

目的:观察中药保留灌肠联合多西环素治疗慢性子宫内膜炎(CE)患者的临床效果。方法:将连云港市妇幼保健院2021年1月—2023年1月收治的60例CE患者以随机数字表法分为试验组、对照组,各30例。试验组给予中药保留灌肠联合多西环素治疗,对照组仅给予多西环素治疗,比较两组疗效、中医症候积分、子宫内膜情况、免疫组化白细胞分化抗原38(CD38)、白细胞分化抗原138(CD138)阳性率及胚胎种植成功率。结果:试验组治疗总有效率(96.67%)高于对照组(76.67%),差异有统计学意义(P<0.05);两组治疗前中医症候积分、子宫内膜厚度及免疫组化CD38、CD138阳性率比较,差异均无统计学意义(P>0.05);治疗后,两组中医症候积分均降低,试验组低于对照组,差异均有统计学意义(P<0.05);两组治疗后子宫内膜厚度均提高,试验组高于对照组,差异均有统计学意义(P<0.05);两组治疗后免疫组化CD38、CD138阳性率均降低,试验组均低于对照组,差异均有统计学意义(P<0.05);试验组胚胎种植成功率(46.67%)高于对照组(20.00%),差异有统计学意义(P<0.05)。结论:针对CE患者以中药保留灌肠联合多西环素治疗临床效果显著,可进一步缓解患者症状,改善子宫内膜厚度,降低免疫组化CD38、CD138阳性率,提高患者胚胎种植成功率。

Objective:To observe the clinical effect of traditional Chinese medicine retention enema combined with Doxycycline in the treatment of patients with chronic endometritis(CE).Method:Sixty patients with CE admitted to Lianyungang Maternal and Child Health Hospital from January 2021 to January 2023 were randomly divided into an experimental group and a control group using a random number table method,with 30 cases in each group.The experimental group was treated with traditional Chinese medicine retention enema combined with Doxycycline,while the control group was only treated with Doxycycline.The therapeutic effects,traditional Chinese medicine syndrome scores,endometrial condition,immunohistochemical white blood cell differentiation antigen 38(CD38),white blood cell differentiation antigen 138(CD138)positivity rates and embryo implantation success rates were compared between the two groups.Result:The total effective rate of the experimental group(96.67%)was higher than that of the control group(76.67%),and the difference was statistically significant(P<0.05);there were no statistically significant differences in the TCM syndrome score,endometrial thickness and immunohistochemical CD38 and CD138 positivity rates between the two groups before treatment(P>0.05);after treatment,the traditional Chinese medicine syndrome scores of both groups decreased,and that of the experimental group was lower than that of the control group,the differences were statistically significant(P<0.05).The endometrial thickness of both groups increased after treatment,and that of the experimental group was higher than that of the control group,the differences were statistically significant(P<0.05);after treatment,the positive rates of immunohistochemistry CD38 and CD138 decreased in both groups,and those of the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05);the success rate of embryo implantation in the experimental group(46.67%)was higher than that in the control group(20.00%),the difference was statistically significant(P<0.05).Conclusion:The clinical efficacy of traditional Chinese medicine retention enema combined with Doxycycline in the treatment of patients with CE is significant.It can further alleviate symptoms of patient,improve endometrial thickness,reduce immunohistochemical CD38 and CD138 positivity rates,and improve the success rate of embryo implantation in patients.