桥本甲状腺炎病因的研究进展

Research Progress on the Etiology of Hashimoto Thyroiditis

桥本甲状腺炎(HT)是一种常见的自身免疫性疾病,以30~50岁女性多见,发病率逐年上升,随着病情进展,不仅会出现甲状腺功能减退症状,还发现与心血管疾病、不良妊娠结局和恶性肿瘤等具有联系,严重威胁人们的身体健康和生活质量。然而该病病因尚不明确,目前认为其与遗传易感性、环境因素和表观遗传效应有关,随着研究的进一步深入,越来越多的因素被发现与HT的发病相关,本文就HT病因的研究进展做一综述,旨在为HT的防治和早期的科学干预提供一定参考价值。

Hashimoto thyroiditis(HT)is a common autoimmune disease,more common in women aged 30-50 years,the incidence rate increases year by year,with the progression of the disease,not only will appear hypothyroidism symptoms,but also found to be associated with cardiovascular diseases,adverse pregnancy outcomes and malignant tumors,seriously threatening people's health and quality of life.However,the etiology of the disease is still unclear,and it is currently believed to be related to genetic susceptibility,environmental factors and epigenetic effects.With the further development of research,more and more factors have been found to be related to the pathogenesis of HT.This article reviews the research progress on the etiology of HT,aiming to provide some reference value for the prevention and treatment of HT and early scientific intervention.