自闭症谱系障碍患者胼胝体发育不全对语言习得影响的研究进展

Research Progress on the Impact of Agenesis of the Corpus Callosum on Language Acquisition in Patients with Autism Spectrum Disorder

自闭症谱系障碍(autism spectrum disorder,ASD)是一种以刻板行为和社交障碍为主要表现的功能障碍。胼胝体发育不全(AgCC)在临床上属于先天性颅脑畸形,其可分为部分缺失及完全缺失。因ASD至今未有明确病因但在临床表现上与AgCC有较多相似之处,多数ASD患者被发现同时患有AgCC,而语言障碍是患者最为直观的表现,也是ASD患者社会交往功能改善的重点与难点。目前ASD患者伴有AgCC所引发的语言功能障碍引起了全世界的关注,对于ASD患者的诊疗与干预上,我国每年投入大量经济与医疗资源,对家庭和社会来说都产生了巨大的经济负担。该文主要从ASD、AgCC的概述、ASD及AgCC的关系和ASD患者伴随AgCC对语言能力的影响三个方面进行综述,期望今后对ASD伴随AgCC所出现的语言功能障碍有更为直观的了解,为ASD患者语言功能障碍提供理论支持。

Autism spectrum disorder(ASD)is a kind of disorder characterized by stereotyped behavior and social disorder.Agenesis of the corpus callosum(AgCC)is a congenital brain malformation clinically,which can be divided into partial absence and complete absence.Because ASD has no clear cause but has many similarities with AgCC in clinical manifestations,most ASD patients are found to have AgCC at the same time.Language disorder is the most intuitive manifestation of the patients,and it is also the focus and difficulty for the improvement of social interaction function of ASD patients.At present,the language dysfunction caused by ASD patients accompanied with AgCC has attracted worldwide attention.In terms of diagnosis and intervention of ASD patients,China has invested a lot of financial and medical resources every year,which create a huge economic burden on families and society.This paper mainly reviews the overview of ASD and AgCC,the relation between ASD and AgCC,and the influence of ASD patients accompanied with AgCC on language ability.It is expected to have a more intuitive understanding of the language dysfunction caused by ASD accompanied with AgCC in the future,and provide theoretical support for the language dysfunction of ASD patients.