免疫细胞在肾脏缺血再灌注损伤修复中的作用研究进展

The role of immune cells in renal ischemia-reperfusion injury and repair

急性肾损伤(AKI)是一种常见的临床综合征,我国住院人群AKI的发病率高达11.6%,AKI发生后容易进展为慢性肾病(CKD)甚至终末期肾病(ESRD)。缺血再灌注损伤(IRI)是AKI的主要病因之一。肾小管上皮细胞是IRI致AKI发生过程中受损的主要细胞类型,也是肾脏修复过程中细胞再生的主要细胞来源。在AKI发生发展以及损伤修复的过程中,免疫细胞能够调节肾小管上皮细胞的损伤、增殖以及再上皮化等多种生物过程,最终导致AKI的不同结局。本文就IRI导致的AKI发生过程中免疫细胞发挥的作用以及领域内的挑战和发展作一综述。

Acute kidney injury(AKI)is a common clinical syndrome.The total incidence of AKI in hospitalized population in China is as high as 11.6%,and the occurrence of AKI is easy to progress to chronic kidney disease(CKD)and even end-stage renal disease(ESRD).Ischemia-reperfusion injury(IRI)is one of the major causes of AKI.Renal tubular epithelial cells are the main cell types damaged in the process of IRI induced AKI,and also the main cell source of cell regeneration in the process of kidney repair.During the development and repair of AKI,immune cells regulate the damage,proliferation and re-epithelialization of renal tubular epithelial cells and other biological processes,which eventually lead to different outcomes of AKI.In this paper,the role of immune cells in the process of AKI induced by IRI and the challenges and developments in the field are reviewed.