蒲元和胃胶囊联合四联疗法对Hp感染蒙古沙鼠的疗效

The efficacy of Puyuanhewei capsules combined with quadruple therapy on Hp-infected mongolian gerbils

目的 观察蒲元和胃胶囊联合四联疗法对幽门螺旋杆菌(Hp)感染蒙古沙鼠的治疗效果。方法制备Hp感染蒙古沙鼠模型,造模成功的蒙古沙鼠随机分为联合治疗组、常规治疗组和模型组,另取同批未建模蒙古沙鼠为对照组,每组12只,雌雄各半。常规治疗组采用艾司奥美拉唑、枸橼酸铋钾、克拉霉素、阿莫西林治疗,联合治疗组采用蒲元和胃胶覆、艾司奥美拉唑、枸橼酸铋钾、克拉霉素、阿莫西林治疗,对照组及模型组给予生理盐水。每天均给药2次,连续14天。分别在给药第10天和14天时取材评价疗效。结果 与模型组相比,给药10天时,联合治疗组蒙古沙鼠的一般状况、体重变化、胃内pH值、快速尿素酶试验、胃组织活菌计数以及胃黏膜病理结果均有明显改善。其结果与常规治疗组14天时相当。结论蒲元和胃胶囊联合四联疗法比常规四联疗法对Hp感染蒙古沙鼠的治疗效果更好,且治疗10天时就已有明显疗效。

Objective To observe the efficacy of Puyuanhewei capsules combined with quadruple therapy on helicobacter pylori(Hp)infected mongolian gerbils.Methods The Hp-infected mongolian gerbil model was built.These modeled gerbils were randomly divided into the combination treatment group,the conventional treatment group and the model group;the unmodeled mongolian gerbils were selected as the control group.Each group had 12 cases(sex ratio of 1:1).Esomeprazole,bismuth potassium citrate,clarithromycin,and amoxicillin were administered in the conventional treatment group.Puyuanhewei capsules were added in the combination treatment group on the basis of the conventional treatment group.Saline was administered in the control group and the model group.All were administered twice a day for 14 days.The efficacy was assessed at the tenth day and fourteenth day.Results At the tenth day of administration,the results of general physical condition,body weight,intragastric pH value,rapid urease test,viable bacteria count in gastric tissues and pathological results of gastric mucosa in the combination treatment group were significantly improved compared to those in the model group.Meanwhile,the results were similar to those of the conventional treatment group at fourteenth day.Conclusion The combination of Puyuanhewei capsules with quadruple therapy was more effective than the conventional quadruple therapy in the traetment of Hp-infected mongolian gerbils,and significant efficacy was observed at the tenth day of treatment.