Th17/Treg免疫平衡治疗气道炎症的研究进展

Research advances of Th17/Treg immune balance in the treatment of airway inflammation

辅助性T细胞17(Th17)和调节性T细胞(Treg)共同来自幼稚的CD4+T淋巴细胞。研究显示,在气道炎症中Th17细胞对炎症有促进作用,而Treg细胞抑制自身免疫。Th17和Treg细胞比例失衡会促使气道炎症的出现。因此,维持Th17/Treg细胞免疫平衡在气道炎症的治疗上至关重要。同时,一些影响这些细胞产生和维持的调节因子也很重要,包括T细胞受体信号、共刺激信号、细胞因子信号等。本文就Th17/Treg细胞与这些调节因子之间的平衡的功能、作用及其在慢性阻塞性肺疾病和支气管哮喘中的临床意义进行阐述。

Helper T cell 17(Th17)and Regulatory T cell(Treg)are derived from naive CD4+T lymphocytes.In airway inflammation,Th17 cells can promote inflammation,while Treg cells can inhibit autoimmunity.The imbalance of Th17 and Treg cells can promote airway inflammation.Therefore,maintaining Th17/Treg cell immune balance is important in the treatment of airway inflammation.At the same time,some regulatory factors that affect the production and maintenance of these cells are also important,including T cell receptor signals,co-stimulatory signals,cytokine signals,etc.This article reviews the function and role of the Th17/Treg cells balance in chronic obstructive pulmonary disease and in bronchial asthma,so as to explore the clinical significance of the balance.