肝癌综合治疗新格局

A new pattern of comprehensive treatment for hepatocellular carcinoma

外科手术是肝癌最主要的根治性治疗方式。我国中晚期肝癌比例高,初诊时手术切除率低,且术后复发率高,严重威胁人民生命健康。随着新型治疗药物的问世和治疗理念的更新,肝癌综合治疗进入全新时代。以靶向治疗、免疫治疗为代表的系统治疗,以介入、放疗为代表的非手术局部治疗,以及系统治疗和局部治疗的联合,显著提高了治疗有效率,为患者带来希望。笔者回顾既往研究,总结团队诊断与治疗经验,系统阐述靶向、免疫治疗时代以外科治疗为主的肝癌综合治疗策略。

Surgical treatment is the primary curative approach for hepatocellular carcinoma(HCC).In China,the proportion of advanced HCC is high,with a low rate of surgical removal at initial diagnosis and a high rate of postoperative recurrence,posing a serious threat to public health.With the advent of new therapeutic drugs and updated treatment concepts,the comprehensive treatment of HCC has entered a new era.Systemic treatments represented by targeted therapy and immunotherapy,non-surgical local treatments such as interventional and radiotherapy,and the combination of systemic and local treatments,have significantly improved the treatment efficacy,bringing hope to patients.The authors review past studies,summarize diagnostic and treatment experience,and discuss the comprehensive treatment strategy for HCC in the era of targeted and immunotherapy,with surgery as the main approach.