Maresin-1对脓毒症器官保护作用的研究进展

Research progress on the organ-protective effect of Maresin-1 in sepsis

脓毒症是宿主对感染产生的炎症反应失控而导致的致命性器官功能障碍。过度炎症反应是脓毒症发生发展的核心环节,器官功能损伤程度与脓毒症预后直接相关,及时干预过度炎症反应、缓解器官功能损伤是改善脓毒症预后的关键。Maresin-1(MaR-1)是一种新近发现的内源性特异性促炎症消退介质,可在脓毒症中发挥抗炎、促炎症消退及器官保护作用,可能是脓毒症治疗的新靶点。本文就MaR-1参与脓毒症炎症调控的机制及其器官保护作用的相关研究进展进行综述,以期为临床研发新的脓毒症治疗药物提供参考依据。

Sepsis is a fatal organ dysfunction caused by the uncontrolled inflammatory response of the host to infection.Excessive inflammatory reaction is the core factor in the occurrence and development of sepsis,the degree of organ dysfunction is directly related to the prognosis of sepsis.Timely intervention of excessive inflammatory response and alleviation of organ function damage are essential to improve the prognosis of sepsis.Maresin-1(MaR-1)is a newly discovered endogenous specific pro-inflammatory resolution mediator,which plays a role of anti-inflammatory,pro-inflammatory regression and organ protection in sepsis,and may be a new target for the treatment of sepsis.This article reviews the research progress of the role of MaR-1 in the regulation of inflammation and organ protection in sepsis,in order to provide reference for the clinical development of new drugs for the treatment of sepsis.