糖代谢重编程及其靶向治疗药物在炎症相关疾病中的作用

The role of glucose metabolism reprogramming and its targeted therapeutic agents in inflammation-related diseases

细胞在炎性微环境影响下发生糖代谢重编程,使其主要供能方式由氧化磷酸化转变为有氧糖酵解,该过程参与炎症相关疾病发生发展的各个阶段。糖代谢重编程不仅改变单个细胞的代谢模式,而且打破了机体微环境的代谢稳态,进一步促进细胞有氧糖酵解,为炎症相关疾病的恶性进展提供有利条件。有氧糖酵解的相关代谢酶、转运蛋白、代谢产物等均为关键信号分子,药物通过靶向这些特异性强的关键分子,抑制有氧糖酵解从而发挥治疗作用。本文围绕糖代谢重编程对炎症相关肿瘤、类风湿关节炎、阿尔茨海默病等炎症相关疾病发生发展的影响以及药物靶向糖代谢重编程对疾病的治疗作用展开综述。

Cells undergo glucose metabolism reprogramming under the influence of the inflammatory microenvironment,changing their primary mode of energy supply from oxidative phosphorylation to aerobic glycolysis.This process is involved in all stages of inflammation-related diseases development.Glucose metabolism reprogramming not only changes the metabolic pattern of individual cells,but also disrupts the metabolic homeostasis of the body microenvironment,which further promotes aerobic glycolysis and provides favourable conditions for the malignant progression of inflammation-related diseases.The metabolic enzymes,transporter proteins,and metabolites of aerobic glycolysis are all key signalling molecules,and drugs can inhibit aerobic glycolysis by targeting these specific key molecules to exert therapeutic effects.This paper reviews the impact of glucose metabolism reprogramming on the development of inflammation-related diseases such as inflammation-related tumours,rheumatoid arthritis and Alzheimer's disease,and the therapeutic effects of drugs targeting glucose metabolism reprogramming on these diseases.