细胞膜结构脂质与膜流动性影响肿瘤侵袭转移的研究进展

Recent progress on the effects of structured lipids and fluidity of plasma membrane on tumor metastasis

恶性肿瘤癌变过程中细胞膜脂质构成发生显著变化,并影响膜流动性和功能。细胞膜流动性涉及肿瘤侵袭转移的多个步骤,包括细胞运动、黏附、膜分子横向扩散、信号传导、物质交换等活动。本文探讨了正常细胞和恶性肿瘤细胞的膜脂质构成和流动性差异,以及与癌细胞侵袭转移潜力之间的相关性,并指出通过改善细胞膜流动性或干扰膜脂质构成,能够抑制肿瘤增殖、侵袭和转移,这种思路更侧重于改变细胞膜的生物物理特性,为预防和治疗癌症转移提供了一种新策略。

The lipid composition of cell plasma membranes of aggressive tumors is significantly altered from normal,affecting the membrane fluidity and function.Plasma membrane fluidity involves multiple steps in tumor invasion and metastasis,including cell movement,adhesion,lateral diffusion of membrane molecules,signal transduction,material exchange and so on.This review highlights the difference in plasma membrane lipid composition and fluidity between normal and cancer cells,as well as the correlation with the invasion and metastasis potential of cancer.We also point out that the proliferation,invasion and metastasis of tumors can be inhibited by improving membrane fluidity or interfering with the membrane structured lipid composition,this focusing more on changing the biophysical properties of cancer cell membranes,and providing a novel strategy that works for treatment of tumor metastasis.