利妥昔单抗致尿蛋白升高1例

Urine protein increase caused by rituximab:a case report

1例50岁女性患者为治疗磷酸酶A2受体相关膜性肾病首次输注利妥昔单抗,用药1 d后检测24 h尿蛋白较前显著升高,18 d后复测24 h尿蛋白定量降至用药前水平。后续再次使用利妥昔单抗出现上述同样情况,考虑为利妥昔单抗的不良反应,尿蛋白升高不除外与该药物从尿液丢失有关。本文分析1例应用利妥昔单抗导致尿蛋白升高的不良反应,以期引起临床重视。

A 50-year-old female patient received the first infusion of Rituximab for the treatment of phosphatase A2 receptor-associated membranous nephropathy,buT_(2)4 h urine protein increased significantly aT_(1)day after medication,and the 24 h urine protein quantification returned to pre-drug levels after 18 days.When rituximab was injected again later,the same symptoms as above appeared,which was considered to be the adverse reaction of rituximab,and the increased urine protein may be associated with the loss of the drug from urine.In this paper,adverse reaction of 1 case of urine protein increase caused by rituximab was analyzed and reported,so as to attract clinical attention.