子宫内膜乳酸杆菌主导的微生物群与生殖的关系

Relationship between endometrial lactobacillus⁃dominated microbiota and reproduction

近年来,越来越多的研究关注了女性子宫内膜微生物群与生育的关联。一旦子宫内膜微生物菌群微生态失调,就会引起一系列子宫内膜病变,从而破坏子宫内膜容受性,影响胚胎植入,导致胚胎着床或移植种植失败。其中,最引发关注的是宫内膜乳酸杆菌主导的微生物群对生殖结局的积极意义,虽然子宫内膜微生物群与生殖结局的关系尚未达成共识,但多数研究认可乳酸杆菌主导的微生物群对生殖的积极影响。笔者检索近年来相关文献,为乳酸杆菌主导的微生物群与生殖结局的关系作一综述。

An increasing number of studies in recent years have focused on the association between female endometrial microbiota and fertility.Once the endometrial microflora microecology is unbalanced,it will cause a series of endometrial lesions,thereby destroying endometrial receptivity,affecting embryo implantation,resulting in embryo implantation or implantation failure.Among them,the most concerned is the positive significance of lactobacillus-led microbiota on reproductive outcome.Although the relationship between endometrial microbiota and reproductive outcome has not reached a consensus,most studies recognize the positive impact of lactobacillus-led microbiota on reproductive outcome.In this review,the relationship between lactobacillus-dominated microbiota and reproductive outcome is reviewed.