摘要
卒中后认知障碍(PSCI)指由卒中引起的一系列认知受损的临床综合征。尽管目前尚不清楚其具体的发病机制,但不少研究已证实内质网-线粒体间的交互串扰作为细胞内信号转导和物质代谢的关键枢纽,其调控的Ca^(2+)稳态、脂质代谢、线粒体动力学、自噬、神经炎症等多种生物学过程与PSCI的发生发展密切相关。因此,本文将对内质网-线粒体互作的生物学功能进行综述,并探讨其在PSCI中的具体作用,以发现新的治疗靶点,为今后PSCI靶向药物的开发提供新的理论依据和参考。
Post-stroke cognitive impairment(PSCI),refers to a range of clinical syndromes of cognitive impairment caused by stroke.Although its specific pathogenesis is still unclear,many studies have confirmed that endoplasmic reticulum-mitochondria interaction has become a key hub for intracellular signal transduction and substance metabolism,and its regulation of various biological processes,such as Ca^(2+)balance,lipid metabolism,mitochondrial dynamics,autophagy,and neuroinflammation,is closely related to the development of PSCI.There⁃fore,in this paper,we will review the various functions of endoplasmic reticulum-mitochondrial interactions and explore their specific roles in PSCI,in order to discover new therapeutic targets and provide new theoretical basis and references for the development of PSCI-targeted drugs in the future.
作者
陈露露
罗萌
苏凯奇
高静
冯晓东
CHEN Lulu;LUO Meng;SU Kaiqi;GAO Jing;FENG Xiaodong(He′nan University of Chinese Medicine,Zhengzhou 450046,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第7期1023-1028,共6页
The Journal of Practical Medicine
基金
国家自然科学基金面上项目(编号:82174473)
国家自然科学基金联合基金(编号:U2004131)
国家自然科学基金青年基金项目(编号:82305364)
河南省科技研发计划联合基金(优势学科培育类)项目(编号:232301420082)。
关键词
脑卒中
认知障碍
内质网线粒体互作
线粒体动力学
自噬
综述
stroke
cognitive impairment
endoplasmic reticulum mitochondrial interactions
mito⁃chondrial dynamics
autophagy
review