miR-126在脑梗死取栓术预后的临床意义

Clinical significance of miR-126 in prognosis of cerebral infarction after thrombectomy

目的通过检测血清微小RNA-126(miR-126)在急性脑梗死介入取栓术治疗前的改变,探讨其与患者预后的相关性。方法回顾性分析2019年1月至2021年12月在湖州市第一人民医院行介入取栓术的脑梗死患者101例,随访2个月,根据改良Rankin评分(modified Rankin scale,mRS)分为预后良好组(mRS≤2分,56例)和预后不良组(mRS>2分,45例),比较两组患者的临床资料及miR-126在取栓术前的差异,分析血清miR-126改变对脑梗死患者预后的影响。结果取栓术前血清miR-126水平在预后良好组明显高于预后不良组[(9.31±2.14)vs.(1.36±0.28),P<0.01],且miR-126与美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分呈负相关(r=–0.737,P<0.01),与侧支循环良好呈正相关(r=0.645,P<0.01),创建miR-126预测脑梗死取栓术预后的受试者操作特征曲线下面积为0.818,最佳截断值敏感度78.9%、特异性86.0%。结论血清miR-126水平在脑梗死取栓术前的改变与患者预后可能相关,可作为早期预测脑梗死介入治疗预后的标志物。

Objective To detect the changes of serum microRNA-126(miR-126)before interventional thrombectomy for acute cerebral infarction,and to explore its correlation with the prognosis of patients.Methods A retrospective analysis was performed on 101 patients with cerebral infarction who underwent interventional thrombectomy in he First People’s Hospital of Huzhou from January 2019 to December 2021.The patients were followed up for 2 month.According to modified Rankin scale(mRS),they were divided into good prognosis group(mRS≤2 points,56 cases)and poor prognosis group(mRS>2 points,45 cases).The clinical data of two groups and the difference of miR-126 before thrombectomy were compared,and the effect of serum miR-126 change on the prognosis of patients with cerebral infarction was analyzed.Results The serum miR-126 level before thromrectomy in good prognosis group was significantly higher than that in poor prognosis group[(9.31±2.14)vs.(1.36±0.28),P<0.01].There was a negative correlation between miR-126 and National Institute of Health stroke scale(NIHSS)score(r=–0.737,P<0.01),and a positive correlation between miR-126 and good collateral circulation(r=0.645,P<0.01).The area under the receiver operating characteristic curve for establishing miR-126 to predict prognosis after thrombolectomy for cerebral infarction was 0.818.The sensitivity and specificity were 78.9%and 86.0%at the optimal cut-off value.Conclusion The change of serum miR-126 level before thrombectomy may be related to the prognosis of patients with cerebral infarction,which can be used as a marker to predict the prognosis of cerebral infarction after interventional therapy.