摘要
目的:探讨肌球蛋白抑制剂(CMI)治疗肥厚型心肌病(HCM)的安全性和有效性。方法:在7个数据库中搜索了建库以来所有关于CMI治疗HCM的随机对照试验(RCTs),并将数据汇总分析,计算优势比及其95%置信区间(CI)。结果:共有6项RCTs(621名患者)被纳入。与接受HCM基础治疗相比,CMI可以使左心室射血分数(LVEF),二尖瓣左室舒张早期血流峰值速度/二尖瓣环根部舒张早期峰值速度(E/e′)、左心房容积指数(LAVi),达到室间隔缩小术(SRT)标准的人数、N-端B型利钠肽前体(NT-proBNP)和左心室流出道(LVOT)压差均显著降低,显著改善堪萨斯城心肌病问卷临床总评分(KCCQ-CSS)。结论:CMI可以抑制HCM患者的心肌过度收缩并且改善其舒张功能和预后。服用CMI与严重不良反应(SAE)无关。
Objective:To investigate the safety and efficacy of cardiac myosin inhibitors(CMI)in the treatment of hypertrophic cardiomyopathy(HCM).Methods:We searched for all randomized controlled trials(RCTs)about CMI for HCM in 7 databases.Data were pooled into a stratified meta-analysis and the odds ratio,and its corresponding 95%confidence interval(CI)were calculated.Results:A total of six RCTs(621 patients)were included.Compared with placebo,CMI decreased left ventricular ejection fraction(LVEF),E/e',left atrial volume index(LAVi),the number of patients who met septal reduction therapy(SRT)guidelines,NT-proBNP,and left ventricular outflow tract(LVOT).KCCQ-CSS was significantly improved.Conclusion:CMI could inhibit myocardial systolic function and improve diastolic function and prognosis in patients with HCM.The administration of CMI was not associated with serious adverse events.
作者
胡方振
周雅文
曾庆红
王杨淦
HU Fangzhen;ZHOU Yawen;ZENG Qinghong;WANG Yanggan(Dept.of Cardiology,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China)
出处
《武汉大学学报(医学版)》
CAS
2024年第2期235-242,共8页
Medical Journal of Wuhan University
基金
国家自然科学基金资助项目(编号:82070348)。
关键词
肌球蛋白抑制剂
随机对照试验
肥厚型心肌病
META分析
Hypertrophic Cardiomyopathy
Randomized Controlled Trials
Cardiac Myosin Inhibitors
Meta Analysis