瑞马唑仑在围术期改善认知功能作用的研究现状

Research status of the role of remimazolam in improving cognitive function during perioperative period

术后认知功能障碍(POCD)是围术期常见并发症之一,在老年患者有较高发病率,而在手术刺激下大量产生神经炎症因子是术后发生POCD主要原因。瑞马唑仑作为γ-氨基丁酸受体激动药的超短效苯二氮[艹卓]类药物,在临床上发挥镇静催眠、抗焦虑作用,同时可以通过抑制神经炎症反应和氧化应激等途径来减轻中枢神经系统内炎症因子改善术后认知功能障碍的作用。本文就瑞马唑仑对术后认知功能的保护作用以及机制进行综述,为瑞马唑仑临床使用提供依据。

Postoperative cognitive dysfunction(POCD) is one of the common complications in the perioperative period,and it has a high incidence in elderly patients,and the large production of neuroinflammatory factors under surgical stimulation is the main cause of postoperative POCD.As an ultra-short-acting benzodiazepine of γ-aminobutyric acid receptor agonist,remimazolam can play a sedative-hypnotic and anxiolytic role in clinical practice,and can reduce inflammatory factors in the central nervous system and improve postoperative cognitive dysfunction by inhibiting neuroinflammatory response and oxidative stress.This article reviews the protective effect and mechanism of remimazolam on postoperative cognitive function,so as to provide a basis for the clinical use of remimazolam.