中药溻渍联合皮内针治疗肺炎支原体肺炎临床疗效及患儿免疫功能、炎症因子水平观察

Effect of Chinese herbal medicine soaking combined with intradermal needling on clinical efficacy,immune function and inflammatory cytokines in children with mycoplasma pneumoniae pneumonia

目的观察中药溻渍联合皮内针治疗肺炎支原体肺炎(MPP)患儿的临床疗效,及其对患儿T淋巴细胞亚群和炎症细胞因子的影响。方法回顾性分析2022年1月—2022年12月首都医科大学附属北京儿童医院住院的71例诊断为肺炎支原体肺炎的患儿资料,所有患儿均接受阿奇霉素静脉滴注治疗,止咳化痰、退热、氧气支持及吸痰等基础治疗,观察组在此基础上采用中药溻渍联合皮内针辅助治疗。比较两组临床疗效、症状改善时间、治疗前后T淋巴细胞亚群及血清炎症因子水平。结果观察组总有效率高于对照组(P<0.05);观察组退热时间、肺部啰音消失时间、咳嗽缓解时间、X线肺部阴影消失时间、平均住院日较对照组均明显缩短(P<0.05)。治疗后,对照组CD8^(+)、CRP、IL-5、IL-6、IFN-γ水平较治疗前下降,CD4^(+)、CD4^(+)/CD8^(+)水平较治疗前升高,差异有统计学意义(P<0.05);观察组CD8^(+)、CRP、IL-5、IL-6、IFN-γ水平较治疗前下降,CD4^(+)、CD4^(+)/CD8^(+)水平较治疗前升高,差异有统计学意义(P<0.05)。结论中药溻渍联合皮内针辅助治疗能明显缩短治疗起效时间,提高临床疗效,并可改善患儿免疫功能紊乱、减轻炎症反应。

Objective To observe the effect of Chinese herbal medicine soaking with intradermal needling on clinical efficacy,T lymphocyte subsets and inflammatory cytokines in children with mycoplasma pneumoniae pneumonia.Methods The data of 71 children diagnosed as mycoplasma pneumoniae pneumonia in Beijing Children's Hospital affiliated to Capital Medical University from January 2022 to December 2022 were analyzed retrospectively.All children received intravenous drip of Azithromycin and symptomatic treatment,including cough and expectoration,antipyretic,oxygen support and sputum aspiration.On the basis of the control group,traditional Chinese herbal medicine soaking with intradermal needling were used for auxiliary treatment.The clinical efficacy,improvement time of clinical symptoms,T lymphocyte subsets before and after treatment,and serum inflammatory factor levels between the two groups were compared.Result The total effective rate of the observation group was higher than that of the control group(P<0.05);the observation group showed significantly shorter fever relief time,lung rale disappearance time,cough relief time,X-ray lung shadow disappearance time,and average hospitalization days compared to the control group(P<0.05).There was no statistically significant difference in the levels of peripheral blood T lymphocyte subsets and inflammatory factors between the control group and the observation group before and after treatment(P>0.05).After treatment,CD8^(+),CRP,IL-5、IL-6,IFN-γ level decreased compared to before treatment in the control group,while the levels of CD4^(+)and CD4^(+)/CD8^(+)increased significantly(P<0.05);CD8^(+),CRP,IL-5,IL-6,IFN-γ level decreased after treatment compared to before treatment in observation group,while the levels of CD4^(+)and CD4^(+)/CD8^(+)increased significantly(P<0.05).Conclusion On the basis of Azithromycin intravenous therapy,the combination of Chinese herbal medicine soaking with intradermal needling can significantly shorten the time of fever relief,the time of lung rale disappearance,the time of cough relief,the time of X-ray lung shadow disappearance and the average hospitalization days in children,and the therapeutic effect is better than that of children who only accepted Azithromycin intravenous therapy.And it can improve the immune dysfunction of children and reduce inflammatory reactions.