流通池法检测西吡氯铵含片的溶出度

Dissolution Determination for Cetylpyridinium Chloride Buccal Tablets by Flow-through Cell Method

采用流通池法检测西吡氯铵(1)含片的溶出度,并对溶出介质浓度、玻璃珠构建方式和用量、流通池流速进行了优化,同时使用建立的方法检测自制样品和参比样品的溶出曲线。结果显示,溶出介质浓度、玻璃珠用量对释放行为的影响不大,不同的玻璃珠构建方式和流通池流速对释放行为的影响较大。本法具有一定的可行性和区分能力,可用于评价1含片的体外溶出行为。

The dissolution of cetylpyridinium chloride(1)buccal tablets was determined by flow-through cell method,and the concentration of the dissolution medium,the construction method and amount of glass beads,and the flow rate of the flow-through cell were optimized.Meanwhile,the dissolution curves of the self-made and reference samples were tested using the established method.The results showed that the concentration of the dissolution medium and the amount of glass beads had little effect on the release behavior,while different glass bead construction methods and flow rates of the flow-through cell had a significant effect on the release behavior.This method has certain feasibility and discriminatory ability,which can be used to evaluate the in vitro dissolution behavior of 1 buccal tablets.