涤痰化瘀理神方治疗精神分裂症疗效观察及对血清BDNF水平的影响

Observation of Ditan Huayu Lishen Prescription for Schizophrenia and Its Effect on BDNF Levels in Serum

目的:观察涤痰化瘀理神方治疗精神分裂症的临床疗效及对血清脑源性神经营养因子(BDNF)水平的影响。方法:按随机数字表法将94例精神分裂症患者分为对照组和研究组各47例。对照组给予奥氮平片、阿立哌唑片治疗,研究组在对照组基础上加用涤痰化瘀理神方治疗。治疗3个月后,比较2组临床疗效,以及治疗前后阳性与阴性症状量表(PANSS)评分、蒙特利尔认知评估量表(MoCA)评分及血清BDNF水平。结果:研究组总有效率为91.49%,对照组为76.60%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组PANSS中阴性症状评分、阳性症状评分、一般病理评分及总分均较治疗前降低(P<0.05),且研究组上述各项评分均低于对照组(P<0.05)。治疗后,2组MoCA量表中视空间与执行功能、定向、记忆、语言、注意、命名、抽象评分及总分均较治疗前升高(P<0.05),且研究组上述各项评分均高于对照组(P<0.05)。治疗后,2组血清BDNF水平均较治疗前升高(P<0.05),且研究组血清BDNF水平高于对照组(P<0.05)。结论:涤痰化瘀理神方辅助治疗精神分裂症有助于提高临床疗效,改善患者精神行为症状及认知功能,有效调节脑源性神经营养因子水平。

Objective:To observe the clinical effect of Ditan Huayu Lishen Prescription on schizophrenia and its effect on levels of brain-derived neurotrophic factor(BDNF)in serum.Methods:A total of 94 patients with schizophrenia were divided into the control group and the study group according to the random number table method,with 47 cases in each group.The control group was treated with Olanzapine Tablets and Aripiprazole Tablets,and the study group was treated with the Ditan Huayu Lishen Prescription based on the treatment of the control group.After 3 months of treatment,the clinical effects were compared between the two groups,and the Positive and Negative Syndrome Scale(PANSS)scores,Montreal Cognitive Assessment(MoCA)scores,and BDNF levels in serum were compared between the two groups before and after treatment.Results:The total effective rate was 91.49%in the study group,and 76.60%in the control group,the difference being significant(P<0.05).After treatment,the negative symptom scores,positive symptom scores,general pathological scores,and total scores of PANSS in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the study group were lower than those in the control group(P<0.05).After treatment,the scores of visual space and executive function,orientation,memory,language,attention,naming,abstraction,and total scores of MoCA in the two groups were increased when compared with those before treatment(P<0.05),and the above scores in the study group were higher than those in the control group(P<0.05).After treatment,the BDNF levels in serum in the two groups were increased when compared with those before treatment(P<0.05),and the BDNF level in serum in the study group was higher than that in the control group(P<0.05).Conclusion:The use of Ditan Huayu Lishen Prescription as an adjunctive therapy for schizophrenia can improve clinical effects,improve patients'mental and behavioral symptoms and cognitive function,and effectively regulate the BDNF levels.