基于数据挖掘总结针刺治疗干燥综合征用穴规律

Summarization of the Point Selection Rules of Acupuncture for the Treatment of Sjogren's Syndrome Based on Data Mining

目的:总结针刺治疗干燥综合征的临床用穴规律,为临床取穴提供参考。方法:通过检索万方数据库、中国知网、维普数据库、PubMed数据库,收集2000—2022年针刺治疗干燥综合征的临床研究文献,通过Microsoft Excel 2010进行频次分析,分别利用SPSS Modeler18.0和SPSS Statistics24.0进行复杂网络、关联规则和聚类分析。结果:筛选文献后纳入48篇文献,共囊括58组针刺处方,覆盖104个腧穴,腧穴使用总频次486次,其中使用频数前三的腧穴依次为三阴交(6.58%)、廉泉(5.76%)、太溪(4.94%)。涉及频数≥10次的高频腧穴有14个,频次共243次,占总频次的50%。使用频数前三的腧穴组合为三阴交-太溪、廉泉-三阴交、廉泉-太溪,出现频次≥10的腧穴组合有19组。选穴涉及十四经脉和经外奇穴,其中使用频次前三的依次为足太阳膀胱经(17.90%)、足阳明胃经(15.23%)、任脉和足太阴脾经(二者并列,11.32%)。通过数据关联规则分析得出针刺治疗干燥综合征的主要组合为三阴交-太冲-太溪。通过聚类分析谱系图得到5个针刺用穴处方。结论:针刺治疗干燥综合征临床疗效可观,主要选择滋阴清热、生津润燥的腧穴为主,以阳经上的腧穴多见,体现了中医阴病治阳的学术思想。

Objective:To summarize the clinical point selection rules of acupuncture in the treatment of Sjogren's syndrome,and to provide reference for clinical acupoint selection.Methods:By searching Wanfang database,CNKI,VIP database and PubMed database,clinical literature on acupuncture for treatment of Sjogren's syndrome from 2000 to 2022 was collected,and frequency analysis was conducted by Microsoft Excel 2010.SPSS Model 18.0 and SPSS Statistics24.0 were used for complex network,association rules and cluster analysis.Results:A total of 48 literature were included after screening,including 58 sets of acupuncture prescriptions,covering 104 acupoints.The total frequency of points used was 486 times,among which the top three points were Sanyinjiao(SP6)(6.58%),Lianquan(RN23)(5.76%),Taixi(KI3)(4.94%).There were 14 high frequency points involving frequencies≥10 times,with a total frequency of 243 times,accounting for 50%of the total frequency.The top three combinations of points used were Sanyinjiao(SP6)-Taixi(KI3),Lianquan(RN23)-Sanyinjiao(SP6),Lianquan(RN23)-Taixi(KI3).There were 19 sets of point combinations with frequency≥10.The selection of points involved 14 meridians and extra nerve points,of which the top three were used in order,bladder meridian of foottaiyang(17.90%),stomach meridian of foot-yangming(15.23%),ren meridian and spleen meridian of foot-taiyin(the two parallel,11.32%).Through the analysis of data association rules,the main combination of acupuncture treatment of Sjogren's syndrome was Sanyinjiao(SP6)-Taichong(LR3)-Taixi(KI3).Five acupuncture point prescriptions were obtained by cluster analysis of pedigree diagram.Conclusion:Acupuncture has considerable clinical effect on Sjogren's syndrome.The main points are those that nourish yin and clear heat,promote fluid and moisten dryness,and the acupoints on yang meridian are more common,which reflects the academic thought of"treating yang at yin disease"in traditional Chinese medicine.