穴位超声药物透入疗法治疗稳定期慢性阻塞性肺疾病临床研究

Clinical Study on Ultrasonic Drug Penetration Therapy at Points for Chronic Obstructive Pulmonary Disease in Stable Stage

目的:观察穴位超声药物透入疗法治疗稳定期慢性阻塞性肺疾病(COPD)的临床疗效。方法:选取100例稳定期COPD患者,根据随机数字表法分为对照组与观察组各50例。对照组给予异丙托溴铵气雾剂、沙丁胺醇吸入气雾剂治疗,观察组在对照组基础上加用保元补肺方穴位超声药物透入疗法治疗。比较2组临床疗效、中医证候评分、肺功能[第1秒用力呼气量(FEV1)、FEV1/用力肺活量(FEV1/FVC),呼气峰流速(PEF)]水平、圣·乔治呼吸问卷(SGRQ)评分及不良反应。结果:观察组总有效率为96.00%,对照组为84.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组主、次症等中医证候评分及总分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。治疗后,2组FEV1、FEV1/FVC、PEF水平均较治疗前升高(P<0.05),且观察组FEV1、FEV1/FVC、PEF水平均高于对照组(P<0.05)。治疗后,2组SGRQ中各项评分及总分较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。治疗期间,2组均未出现明显不良反应。结论:常规西药联合保元补肺方超声药物透入疗法治疗稳定期COPD,有助于改善中医证候,提高患者的肺功能及生活质量。

Objective:To observe the clinical effect of ultrasonic drug penetration therapy at points on chronic obstructive pulmonary disease(COPD)in stable stage.Methods:A total of 100 patients with COPD in stable stage were selected and divided into the control group and the observation group according to the random number table method,with 50 cases in each group.The control group was given Ipratropium Bromide Aerosol and Salbutamol Sulfate Aerosol for treatment,and the observation group was additionally given ultrasonic drug penetration therapy at acupoints of Baoyuan Bufei Prescription based on the treatment of the control group.The clinical effects,traditional Chinese medicine(TCM)syndrome scores,levels of lung function indexes,including forced expiratory volume at first second(FEV1),FEV1/forced vital capacity(FEV1/FVC),and peak expiratory flow(PEF),scores of St George's Respiratory Questionnaire(SGRQ)and incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 96.00%in the observation group and 84.00%in the control group,the difference being significant(P<0.05).After treatment,the TCM syndrome scores of primary and secondary symptoms and the total scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of FEV1,FEV1/FVC and PEF in the two groups were increased when compared with those before treatment(P<0.05),and the above levels in the observation group were higher than those in the control group(P<0.05).After treatment,each score in the SGRQ and the total scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).During treatment,there was no significant adverse reaction in the two groups.Conclusion:The adoption of western medicines combined with ultrasonic drug penetration therapy at acupoints of Baoyuan Bufei Prescription can help improve the TCM syndromes,lung function and quality of life of patients with COPD in stable stage.