坏死性筋膜炎临床研究进展

Progress of clinical research on necrotizing fasciitis

坏死性筋膜炎(NF)是一种严重的皮肤及软组织侵袭性感染,其特征是皮下组织尤其是浅层和深层筋膜迅速进行性坏死,发病率低,但病死率高,达20%~30%。NF早期识别困难,诊断标准不明确,病情进展迅速,因此,早期的及时诊治是提高NF患者生存率和改善生存质量的关键。近年来,随着新的诊断方式和治疗药物不断涌现,新的生物标志物研究为NF的诊断及分型提供了新思路,而关于该病的机制研究和新药研发延伸出了多种NF治疗方案。本文旨在综述NF发病原因及危险因素,总结NF的临床表现、分型及鉴别,探索NF的诊断和治疗方法,从而为后续相关研究提供参考。

OBJECTIVE Necrotizing fasciitis(NF)is a severe and aggressive skin and soft tissue infection character-ized by rapidly progressive necrosis of subcutaneous tissues,especially superficial and deep fascia,the morbidity is low,but the mortality rate is high,ranging between 20%and 30%.Because of the difficult identification of NF in early stage,unclear diagnostic criteria and rapid progression,the early and timely diagnosis and treatment is the key to raise the survival rate and improve the life quality of the NF patients.In recent years,the diagnostic modes and therapeutic drugs have emerged,the research on novel biomarkers,provides new ideas for the diagnosis and typing of NF.The research on pathogenesis mechanisms of the disease and development of new drugs have brought out a variety of treatment programs for NF.The article focuses on review of the causes and risk factors for the NF,summarize the clinical manifestations,typing and identification of NF,and explore the diagnosis and treatment methods for NF so as to provide reference for subsequent studies.