小剂量阿司匹林联合钙剂、维生素E治疗对妊娠期高血压UPR、MAP、凝血指标的影响

Effects of low⁃dose aspirin combined with calcium and vitamin E treatment on UPR,MAP and coagulation indexes of pregnancy⁃induced hypertension

目的 分析小剂量阿司匹林联合钙剂、维生素E在妊娠期高血压中的治疗效果及对尿蛋白(UPR)、平均动脉压(MAP)、凝血指标的影响。方法 选取2017年7月至2022年7月于河南省第二人民医院就诊的122例妊娠期高血压患者,根据治疗方式不同分为对照组(n=60,硫酸镁治疗)和研究组(n=62,小剂量阿司匹林联合钙剂、维生素E治疗)。比较两组治疗效果及UPR、MAP、UA、CysC及凝血指标水平,观察不良反应发生情况。结果 研究组治疗总有效率(95.16%)显著高于对照组(81.67%),差异有统计学意义(P<0.05);治疗后研究组MAP、UPR、UA及CysC水平均低于对照组,差异有统计学意义(P<0.05);治疗后研究组PT、TT、APTT长于对照组,FIB低于对照组,差异有统计学意义(P<0.05);研究组不良反应率(17.74%)与对照组不良反应率(8.33%)比较,差异无统计学意义(P>0.05)。结论 采用小剂量阿司匹林联合钙剂、维生素E治疗妊娠期高血压患者的疗效显著,可有效改善患者的UPR水平及凝血指标,有利于控制患者血压,安全性尚可,具有一定的临床使用价值。

Objective To analyze the therapeutic effects of low-dose aspirin combined with calci-um and vitamin E in gestational hypertension and its effects on urine protein(UPR),mean arterial pressure(MAP)and coagulation indexes.Methods A total of 122 patients with gestational hypertension who were treated at the Second People's Hospital of Henan Province from July 2017 to July 2022,were selected and di-vided into two groups:the control group(n=60,treated with magnesium sulfate treatment)and the study group(n=62,treated with low-dose aspirin combined with calcium and vitamin E).The treatment effects,im-pact on UPR,MAP and coagulation indexes were compared between the two groups,and the occurrence of ad-verse reactions was observed.Results The total effective rate in the study group(95.16%)was significantly higher than that in the control group(81.67%),and the difference was statistically significant(P<0.05).Aaf-ter treatment,the levels of MAP,UPR,UA and CysC in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,PT,TT and APTT in the study group were longer than those in the control group,while FIB was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the adverse re-action rate between the study group(17.74%)and the control group(8.33%)(P>0.05).Conclusion Low-dose aspirin,when combined with calcium and vitamin E,is effective in treating gestational hypertension.This treatment can improve patientsUPR levels and coagulation indicators,helping to control of blood pres-sure.It is safe and has significant clinical value.