益气破血化痰方对冠心病血运重建术后心绞痛患者CRP、Hcy及血管内皮功能的影响

Effects of Yiqi⁃Poxue⁃Huatan Decoction on CRP,Hcy and Vascular Endothelial Function in Patients with Angina Pectoris after Coronary Heart Disease Revascularization

目的 分析益气破血化痰方对冠心病血运重建术后心绞痛患者C-反应蛋白(CRP)、同型半胱氨酸(Hcy)及血管内皮功能的影响。方法 选取2019年10月到2023年1月河南省中西医结合医院收治的82例冠心病血运重建术后心绞痛患者为研究对象,采用随机数字表法将患者分为对照组(常规西医治疗)41例和观察组(常规西医+益气破血化痰方治疗)41例。比较两组治疗效果、CRP、Hcy及血管内皮功能,并统计比较两组治疗安全性。结果 观察组临床总有效率(87.80%)显著高于对照组(60.98%),差异有统计学意义(P<0.05);治疗后两组CRP、Hcy水平均显著降低,且观察组显著低于对照组,差异有统计学意义(P<0.05);治疗后,两组中医证候积分均降低,FMD值均上升,且观察组中医证候积分低于对照组,FMD值高于对照组,差异有统计学意义(P<0.05);观察组治疗安全性显著高于对照组,差异有统计学意义(P<0.05)。结论 益气破血化痰方可明显降低冠心病血运重建术后心绞痛患者CRP、Hcy水平,能更好地改善患者血管内皮功能及中医证候,临床疗效更佳,且具有一定安全性。

Objective To analyze the effects of Yiqi-Poxue-Huatan Decoction on CRP,Hcy,and vascular endothelial function in patients with angina pectoris after coronary heart disease revascularization.Methods 82 patients with angina pectoris after coronary heart disease aevascularization were admitted to Henan Integrative Medicine Hospital from October 2019 to January 2023.They were selected as the research subjects.Using a random number table method,the patients were divided into a control group(treated with conventional Western medicine)of 41 cases and an observation group(treated with conventional Western med-icine+Yiqi-Poxue-Huatan Decoction)of 41 cases.The therapeutic effects,CRP,Hcy,and endothelial func-tion of blood vessels(evaluated using flow-mediated dilation-FMD)were compared between the two groups.Thesafety of treatment in both groups was also statistically compared.Results The total clinical efficacy rate(87.80%)in the observation group was significantly higher than that in the control group(60.98%),with a statistically significant difference(P<0.05).After treatment,levels of CRP and Hcy decreased significantly in both groups with the observation group showing significantly lower levels compared to the control group(P<0.05).TCM syndrome scores decreased and FMD values increased after treatment in both groups.The ob-servation group had lower TCM syndrome scores and higher FMD value compared to the control groupt,with a statistically significant difference(P<0.05).The safety of treatment in the observation group was significantly higher than in the control group,with a statistically significant difference(P<0.05).Conclusion The Yiqi-Poxue-Huatan Decoction can significantly reduce the levels of CRP and Hcy in patients with angina after coro-nary artery revascularization.It also improves the endothelial function of patients and their TCM syndrome.Ad-ditionally,it has shown better clinical efficacy and a certain level of safety.