炎琥宁联合干扰素治疗小儿手足口病的临床效果

Clinical effect of Potassium Sodium Dehydroandrographolide Succinate combined with interferon in the treatment of hand-foot-mouth disease in children

目的观察炎琥宁联合干扰素治疗小儿手足口病的临床效果。方法选取2021年1月至2023年1月商河县人民医院收治的62例手足口病患儿为研究对象,按照随机数字表法将其分为对照组(31例)、治疗组(31例)。对照组采用干扰素治疗,治疗组在对照组基础上采用炎琥宁治疗,比较两组的治疗总有效率、症状消失时间及炎症因子水平。结果治疗组治疗总有效率高于对照组(P<0.05);治疗组退热、皮疹消失及口腔溃疡愈合时间短于对照组(P<0.05);治疗后,治疗组C反应蛋白、白细胞介素-6、肿瘤坏死因子-α水平低于对照组(P<0.05)。结论炎琥宁联合干扰素治疗小儿手足口病的临床效果显著,能够促进症状缓解,减轻炎症反应,值得推广。

Objective To observe the clinical effect of Potassium Sodium Dehydroandrographolide Succinate combined with interferon in the treatment of hand-foot-mouth di sease in children.Methods A total of 62 children with hand-foot-mouth disease in Shanghe People’s Hospital from January 2021 to January 2023 were selected and divided into control group(31 cases)and treatment group(31 cases)by the random number table method.The control group was treated with interferon,while the treatment group was treated with Potassium Sodium Dehydroandrographolide Succinate on the basis of control group.The total effective rate,symptom disappearance time and inflammatory factor levels of the two groups were compared.Results The total effective rate in the treatment group was higher than that in the control group(P<0.05).The time of antipyretic,rash disappearance and oral ulcer healing in the treatment group was earlier than that in the control group(P<0.05).After treatment,the levels of C-creative protein,interleukin-6 and tumor necrosis factor-αin the treatment group were lower than those in the control group(P<0.05).Conclusion The clinical effect of Potassium Sodium Dehydroandrographolide Succinate combined with interferon treating hand-foot-mouth disease in children has significant clinical effect,which can promote the relief of symptoms and reduce inflammation,and is worth promoting.