摘要
农药学基础涉及多个学科门类,与应用结合紧密,是植物保护和动植物检疫专业的核心课程之一。分子对接技术因其高效、低成本、能够为药物设计提供理论指导等优势,在新农药发现与作用机制研究中发挥了重要的作用。本文分析了分子对接技术及其在农药学基础教学中的应用效果。将分子对接技术引入农药学基础教学中,引导学生进行分子对接实验,可以帮助其掌握农药与靶标分子间亲和力和选择性差异的原因,理解农药与靶标分子的相互作用,理解农药抗药性产生机理,理解生物体内的农药代谢行为。还可以帮助学生培养计算机技能,激发创新思维,加强团队协作能力,从而提高教学效果和质量。分子对接技术的引入可以丰富农药学科的课程体系,培养学生的创新意识和科学素养,使学生更好地适应当今农业发展的需求。
The foundation of agricultural pharmacy involves multiple disciplines and is closely integrated with applications.It was one of the core courses of plant protection and animal and plant quarantine.Molecular docking technology had played an important role in the discovery and mechanism of action of new pesticides due to its high efficiency,low cost,and ability to provide theoretical guidance for drug design.This article analyzed the molecular docking technology and its application effect in the teaching of agricultural pharmacy fundamentals.Introducing molecular docking technology into basic teaching of agricultural pharmacy and guiding students to conduct molecular docking experiments could help them understand the reasons for the differences in affinity and selectivity between pesticides and target molecules,understand the interaction between pesticides and target molecules,understand the mechanism of pesticide resistance,and understand the metabolic behavior of pesticides in organisms.It could also help students cultivate computer skills,stimulate innovative thinking,strengthen teamwork ability,and thus improved teaching effectiveness and quality.The introduction of molecular docking technology could enrich the curriculum system of pesticide discipline,cultivate students,innovative awareness and scientific literacy,and enable them to better adapt to the needs of current agricultural development.
作者
董利利
康占海
马树杰
张利辉
所凤阅
DONG Lili;KANG Zhanhai;MA Shujie;ZHANG Lihui;SUO Fengyue(College of Plant Protection,Hebei Agricultural University,Baoding 071001,China)
出处
《安徽农学通报》
2024年第6期120-123,共4页
Anhui Agricultural Science Bulletin
基金
河北省高等教育教学改革研究与实践项目(2019GJJG092)。
关键词
农药学基础
分子对接
农药设计
Fundamentals of Agropharmacy
molecular docking
pesticide design