自由基不对称反应研究进展

Progresses on Asymmetric Radical Reactions

自1900年第一个稳定的三苯甲基自由基被发现后的很长一段时间内,人们普遍认为自由基很活泼、反应不可控制、产物复杂,所以自由基反应的研究和应用受到了很大的限制,发展缓慢。但近年来的研究表明,自由基反应在一定条件下是可预测、可控制并具备其他方法所没有的很多优点,如:(1)自由基可以在一定的时间内稳定存在;自由基具有高活性,在一定条件下自由基反应具有很好的区域和立体选择性;(2)自由基反应可以容忍很多官能团的存在;(3)自由基反应条件温和,在一定的条件下产率很高。根据不同的反应策略,对近年来可控的自由基不对称反应的研究成果进行了综述,从而为新型的可控自由基反应类型的拓展和开发利用提供一定的参考。

Since the discovery of the first stable radical,triphenylmethyl radical,in 1900,radicals were widely regarded as highly reactive species,leading to uncontrollable and complex reactions.Consequently,the advancement of radical reactions has been significantly impeded.However,recent research has revealed that radical reactions can be predictable and controllable,offering several advantages not found in many other reactions.These advantages include:(1)Relatively stable radicals with high reactivity and excellent regio-and stereo-selectivity;(2)Tolerance of numerous functional groups in radical reactions;(3)Conducting radical reactions under mild conditions,resulting in high yields.Here,this review focuses on recent advancements in controlled radical asymmetric reactions,categorized according to different reaction strategies.The aim is to provide valuable insights and references for the development and utilization of new types of controlled radical reactions.