构建6H-1,3-噁嗪-6-酮的研究进展

Research Progress on the Construction of 6 H-1,3-Oxazine-6-One

6H-1,3-噁嗪-6-酮是一类重要的杂环化合物,广泛应用于有机合成、精细化工和医药领域,且在抗肿瘤、抗疟疾、抗真菌活性等方面都表现出优异的性能,故备受有机合成工作者的关注。近年来,6H-1,3-噁嗪-6-酮骨架的构筑方法和策略取得了长足发展。尤其是通过过渡金属催化机理的偶联反应得到迅速发展。因此,很有必要对其进行梳理。经查阅文献目前尚无相关专题综述对构建6H-1,3-噁嗪-6-酮的合成进行归纳总结,故对6H-1,3-噁嗪-6-酮骨架的构建方法进行详细综述,以期为类似化合物的合成方法提供新思路。

6 H-1,3-oxazine-6-one is a significant heterocyclic compound with wide applications in organic synthesis,the fine chemical industry,and medicine.It exhibits excellent properties in anti-tumor,anti-malaria,and anti-fungal activities,making it a subject of great interest in organic synthesis.In recent years,substantial progress has been made in the construction methods and strategies for the 6 H-1,3-oxazine-6-one backbone,particularly through coupling reactions utilizing transition metal catalysis.However,there is currently no comprehensive review available that summarizes the synthesis of 6 H-1,3-oxazine-6-one.Therefore,this review aims to provide a detailed overview of the construction methods employed for the 6 H-1,3-oxazine-6-one backbone,with the intention of offering new insights and ideas for the synthesis of similar compounds.