代谢相关脂肪性肝病发病机理及治疗的研究进展

Progress in the pathogenesis and treatment of metabolic associated fatty liver disease

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种以肝内脂质沉积为特征的慢性肝病,目前已更名为代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)。近年来MAFLD发病率逐步提升,对医疗系统的负担持续增加,在治疗方面尚无特效药物。本研究通过查阅相关文献,概述了影响MAFLD发病的相关机制,归纳了MAFLD治疗方法的当前进展,为临床治疗MAFLD提供理论基础。

Non-alcoholic fatty liver disease(NAFLD)is a very common chronic liver disease that has been renamed metabolic associated fatty liver disease(MAFLD).In recent years,the incidence of MAFLD has gradually increased,and the burden on the medical system has continued to increase.Currrently,there is no specific treatment for MAFLD.This study outlined the relevant mechanisms used to affect the pathogenesis of MAFLD,summarized the current progress in the treatment of MAFLD,which provided a theoretical basis for the clinical treatment of MAFLD.