卒中后中枢性疼痛的诊断及治疗进展

Progress in Diagnosis and Treatment of Central Post⁃stroke Pain

卒中后中枢性疼痛(central post⁃stroke pain,CPSP)是一种发生于脑卒中后的神经病理性疼痛综合征,其特征为出现疼痛或感觉异常的身体部位由出现血管损伤的大脑区域支配。CPSP患者常伴有焦虑、抑郁等情绪障碍,导致其生活质量降低。然而目前CPSP的发生机制仍未完全阐明,以致临床诊断率不高,常用治疗手段效果欠佳。本文从CPSP的临床特征、流行病学、发生机制及治疗手段等方面展开综述,以期为CPSP的诊断及有效治疗提供参考。

Central post⁃stroke pain(CPSP),a neuropathic pain syndrome occurring after a cere⁃brovascular accident,is characterized by pain or paraesthesia in the part of the body dominated by the area of the brain where blood vessels are injured.CPSP patients are often accompanied by anxiety,depression and other emotional disorders,which have a serious negative impact on patients’quality of life.However,the pathogenesis of CPSP has not been fully elucidated,the clinical diagnosis rate is not high,and the commonly used treatment methods are not effective.This article reviews the clinical features,epidemiology,pathogenesis and treatment of CPSP in order to provide reference for the elucidation of CPSP mechanism and effective treatment.