穿刺活检联合不同涂片技术诊断甲状腺结节良恶性研究

Differential Diagnosis of Benign and Malignant Thyroid Nodules Using Puncture Biopsy Combined with Different Smear Techniques

探讨细针超声引导下穿刺活检联合传统涂片、液基薄层细胞学技术在甲状腺结节良恶性病变诊断中的应用价值。将2021年9月—2022年12月在衢州市柯城区人民医院治疗的75例甲状腺结节患者作为研究对象,均行细针超声引导下穿刺活检(US-FNAB)、传统涂片、液基薄层细胞学技术,以US-FNAB联合传统涂片作为对照组,US-FNAB联合液基薄层细胞学技术作为观察组,以手术病理结果为金标准,对比两组的标本满意率、与病理结果对照、诊断效能、诊断一致性。结果显示,观察组甲状腺结节直径明显长于对照组,标本满意率明显高于对照组(P<0.05);观察组对甲状腺结节诊断的特异度、准确度、阳性预测值高于对照组(P<0.05)。研究发现,US-FNAB联合液基薄层细胞学技术在甲状腺结节良恶性病变诊断鉴别中的应用效果更好,诊断效能更高,与病理结果的一致性更高。

Exploring the application value offine needle ultrasound-guided puncture biopsy combined with traditional smear and liquid based thin-layer cytology techniques in the diagnosis and differentiation of benign and malignant thyroid nodules.75 patients with thyroid nodules treated at Kecheng District People’s Hospital in Quzhou City from September 2021 to December 2022 were selected as the study subjects.All patients underwentfine needle ultrasound-guided puncture biopsy(US-FNAB),traditional smear,and liquid based thin-layer cytology techniques.The US-FNAB combined with traditional smear was used as the control group,and the US-FNAB combined with liquid based thin-layer cytology technique was used as the observation group.The surgical and pathological results were used as the gold standard to compare the sample satisfaction rates between the two groups Comparison with pathological results,diagnostic efficacy,and diagnostic consistency.The diameter of thyroid nodules in the observation group was significantly longer than that in the control group,and the sample satisfaction rate was significantly higher than that in the control group(P<0.05);The specificity,accuracy,and positive predictive value of the observation group in diagnosing thyroid nodules were higher than those of the control group(P<0.05).Research has found that the combination of US-FNAB and liquid based thin-layer cytology technology has better application effect in the diagnosis and differentiation of benign and malignant thyroid nodules,higher diagnostic efficiency,and higher consistency with pathological results.