AMICUS血细胞分离机单采血小板解聚不良的影响因素分析

Analysis of the Influencing Factors of Poor Platelet Depolymerization in AMICUS Blood Cell Separator

目的:探究AMICUS血细胞分离机单采血小板解聚不良的影响因素分析。方法:选择2021年1月~2022年12月本中心献血者共144例作为观察对象,使用AMICUS血细胞分离机单采血小板,分析其具体的解聚不良的影响因素,观察产生的不良情况等。结果:在144例献血者中,出现解聚不良者共36例,均为轻微,解聚不良发生率是25.00%;未发生者共108例。无解聚不良组与解聚不良组的平均血小板体积、血红蛋白、红细胞压积、血小板计数、血小板分布宽度的献血者采前指标,同解聚不良的发生并无关联性(P>0.05);无解聚不良组的产品pH值高于解聚不良组,显示出其和解聚不良存在负相关(r=–0.162,P<0.05);解聚不良组的循环血量和所用采集时间均高于无解聚不良组,显示解聚不良的发生和循环血量、采集时间呈现正相关(r=0.235,P<0.05)、(r=0.1465,P<0.05)。结论:对无偿献血者使用AMICUS血细胞分离机单采血小板需要注意保证一针穿刺成功率,尽量选择血管条件较好、体重较大、循环血量较低的献血者,可不考虑献血者采前血常规指标,站在解聚不良的角度进行分析,临床应用价值较好。

Objective:To investigate the influencing factors of poor platelet depolymerization in AMICUS blood cell separator.Methods:A total of 144 blood donors were selected from January 2021 to December 2022,and platelets were collected using an AMICUS blood cell separator.The specific influencing factors of poor depolymerization were analyzed,and the adverse effects were observed.Results:Among a total of 144 blood donors,36 cases of poor depolymerization occurred in the control group,while 108 cases of non depolymerization occurred in the observation group,all of which were mild.The incidence rate of poor depolymerization was 25.00%;The average platelet volume(MPV),Hb,HCT,PLT,and platelet distribution width(PDW)of blood donors in the observation and control groups were not correlated with the occurrence of poor depolymerization(P>0.05);The pH value of the observed group’s products was higher than that of the control group,indicating a negative correlation with poor depolymerization(r=-0.162,P<0.05);The circulating blood volume and collection time of the control group were higher than those of the observation group,indicating a positive correlation between the occurrence of poor depolymerization and circulating blood volume and collection time(r=0.235,P<0.05),(r=0.1465,P<0.05).Conclusion:For clinical blood donors,by using the AMICUS blood cell separator to collect platelets alone,it is necessary to pay attention to ensuring the success rate of one needle puncture,and try to choose blood donors with good vascular conditions,large body mass,and low circulating blood volume.The preoperative blood routine indicators of the donors may not be considered,and analysis can be conducted from the perspective of poor depolymerization.The clinical application value is better.