“肠-免疫”轴对骨稳态影响的研究进展

Research progress of the effect of“gut-immune”axis on bone homeostasis

骨稳态是基于骨形成和骨吸收的动态平衡,骨稳态失衡是导致包括骨质疏松症在内的多种骨骼疾病的重要基础。肠道菌群(GM)被认为对骨稳态有重要影响,其组成和多样性改变与骨量及骨微结构的变化密切相关,而GM与宿主肠免疫系统相互作用形成的“肠-免疫”轴,除了可以调节机体免疫反应,维持肠道及机体免疫稳态之外,对维持骨稳态平衡起到至关重要的作用。我们总结了GM、免疫系统及其协同作用对骨稳态影响的新研究进展。

Bone homeostasis is based on the dynamic balance of bone formation and bone resorption.An imbalance in bone homeostasis is a major contributor to many skeletal diseases,including osteoporosis.Changes in the composition and diversity of the gut microbiota(GM)are supposed to have a significant impact on bone homeostasis and are closely correlated with changes in bone mass and bone microarchitecture.The“gut-immune"”axis,which is formed by the interaction between the host intestinal immune system and GM,is essential for maintaining bone homeostasis,as well as regulating the bodys immunological response and maintaining immune homeostasis throughout the intestine and body.The article reviews recent advances in the study of GM,the immune system,and their synergistic impact on bone homeostasis.